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Tbio Protein disulfide-isomerase A4

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]

 Comments

Property Summary

NCBI Gene PubMed Count 31
PubMed Score 45.47
PubTator Score 30.01

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Chronic obstructive pulmonary disease 184 0.0 1.0
Disease Target Count Z-score Confidence
Multiple epiphyseal dysplasia 18 3.36 1.7
Wolcott-Rallison syndrome 10 3.106 1.6

Expression

  Differential Expression (31)

Disease log2 FC p
active Crohn's disease 1.077 9.1e-03
adult high grade glioma 1.100 2.7e-03
astrocytoma 1.200 3.6e-02
Astrocytoma, Pilocytic 1.100 2.2e-04
atypical teratoid / rhabdoid tumor 1.100 5.5e-05
Breast cancer 3.300 2.5e-02
cutaneous lupus erythematosus 1.400 1.9e-02
diabetes mellitus -1.400 4.7e-02
ductal carcinoma in situ 1.200 6.9e-04
ependymoma 1.300 2.1e-10
esophageal adenocarcinoma 1.400 1.8e-02
glioblastoma 1.100 5.3e-07
group 3 medulloblastoma 1.100 4.5e-03
intraductal papillary-mucinous adenoma (... 1.100 7.2e-03
intraductal papillary-mucinous carcinoma... 1.700 4.7e-03
intraductal papillary-mucinous neoplasm ... 1.600 3.6e-03
invasive ductal carcinoma 1.300 1.3e-03
lung adenocarcinoma 1.700 1.3e-12
lung cancer 1.200 6.4e-04
non primary Sjogren syndrome sicca 1.100 2.7e-02
non-small cell lung cancer 1.278 1.6e-18
osteosarcoma -2.572 3.0e-06
ovarian cancer 1.700 6.4e-05
pancreatic cancer 1.100 3.1e-02
pancreatic carcinoma 1.100 3.1e-02
pancreatic ductal adenocarcinoma liver m... -1.696 1.6e-03
pituitary cancer -1.400 8.7e-07
primitive neuroectodermal tumor 1.100 3.9e-03
psoriasis -3.500 5.4e-06
subependymal giant cell astrocytoma 1.263 9.8e-03
ulcerative colitis 1.100 2.8e-07

Synonym

Accession P13667 A8K4K6 Q549T6
Symbols ERP70
ERP72
ERp-72

Gene

PDIA4

  Ortholog (13)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG

 UniProt Keyword (12)

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 GO Function (3)

 GO Component (5)

 GO Process (5)

 Compartment GO Term (30)

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 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (16)

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Protein-protein Interaction (1)

EMC7  

PDB (1)

Gene RIF (17)

AA Sequence 

MRPRKAFLLLLLLGLVQLLAVAGAEGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDA      1 - 70
NFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTI     71 - 140
KILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCK    141 - 210
KLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMI    211 - 280
EQSGPPSKEILTLKQVQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKV    281 - 350
SQGQLVVMQPEKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYS    351 - 420
VDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILDESGKKFAMEP    421 - 490
EEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQ    491 - 560
LEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKF    561 - 630
IEEHATKLSRTKEEL                                                           631 - 645
//

Text Mined References (38)

PMID Year Title