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Tbio Protein disulfide-isomerase A4

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]

 Comments

Property Summary

NCBI Gene PubMed Count 31
PubMed Score 45.47
PubTator Score 30.01

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Chronic obstructive pulmonary disease 184 0.0 1.0
Disease Target Count Z-score Confidence
Multiple epiphyseal dysplasia 18 3.36 1.7
Wolcott-Rallison syndrome 10 3.106 1.6

Expression

  Differential Expression (31)

Disease log2 FC p
active Crohn's disease 1.077 9.1e-03
adult high grade glioma 1.100 2.7e-03
astrocytoma 1.200 3.6e-02
Astrocytoma, Pilocytic 1.100 2.2e-04
atypical teratoid / rhabdoid tumor 1.100 5.5e-05
Breast cancer 3.300 2.5e-02
cutaneous lupus erythematosus 1.400 1.9e-02
diabetes mellitus -1.400 4.7e-02
ductal carcinoma in situ 1.200 6.9e-04
ependymoma 1.300 2.1e-10
esophageal adenocarcinoma 1.400 1.8e-02
glioblastoma 1.100 5.3e-07
group 3 medulloblastoma 1.100 4.5e-03
intraductal papillary-mucinous adenoma (... 1.100 7.2e-03
intraductal papillary-mucinous carcinoma... 1.700 4.7e-03
intraductal papillary-mucinous neoplasm ... 1.600 3.6e-03
invasive ductal carcinoma 1.300 1.3e-03
lung adenocarcinoma 1.700 1.3e-12
lung cancer 1.200 6.4e-04
non primary Sjogren syndrome sicca 1.100 2.7e-02
non-small cell lung cancer 1.278 1.6e-18
osteosarcoma -2.572 3.0e-06
ovarian cancer 1.700 6.4e-05
pancreatic cancer 1.100 3.1e-02
pancreatic carcinoma 1.100 3.1e-02
pancreatic ductal adenocarcinoma liver m... -1.696 1.6e-03
pituitary cancer -1.400 8.7e-07
primitive neuroectodermal tumor 1.100 3.9e-03
psoriasis -3.500 5.4e-06
subependymal giant cell astrocytoma 1.263 9.8e-03
ulcerative colitis 1.100 2.8e-07

Synonym

Accession P13667 A8K4K6 Q549T6
Symbols ERP70
ERP72
ERp-72

Gene

PDIA4

PDB

3IDV  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (12)

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 GO Function (3)

 GO Component (5)

 GO Process (5)

 Compartment GO Term (30)

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 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (16)

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Protein-protein Interaction (1)

EMC7  

Gene RIF (17)

AA Sequence 

MRPRKAFLLLLLLGLVQLLAVAGAEGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDA      1 - 70
NFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTI     71 - 140
KILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCK    141 - 210
KLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMI    211 - 280
EQSGPPSKEILTLKQVQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKV    281 - 350
SQGQLVVMQPEKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYS    351 - 420
VDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILDESGKKFAMEP    421 - 490
EEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQ    491 - 560
LEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKF    561 - 630
IEEHATKLSRTKEEL                                                           631 - 645
//

Text Mined References (38)

PMID Year Title