Property Summary

NCBI Gene PubMed Count 14
PubMed Score 39.46
PubTator Score 233.53

Knowledge Summary


No data available


Gene RIF (7)

24675470 c-myc regulated the expression of human PDF.
23815882 This is the first report showing that PDF is over-expressed in breast, colon, and lung cancers
22554513 these data reveals that PDF has several transcription start sites, the most important of which only 18 bp from the initiation codon.
21805148 the origin, evolution and preservation of the COG8/PDF same-strand overlap follow similar mechanistic steps as those documented for antisense overlaps where gain and/or loss of splice sites and polyadenylation signals seems to drive the process.
19236878 Despite the lack of true S2' and S3' binding pockets, confirmed through peptide binding modeling, enzyme kinetics suggest a combined contribution from P2'and P3' positions of a formylated peptide substrate to turnover.
19064571 Observational study of gene-disease association. (HuGE Navigator)
14637138 The inhibition of HsPDF may provide an explanation for the mechanism by which actinonin is cytotoxic against various human tumor cell lines.

AA Sequence

IIQHEMDHLQGCLFIDKMDSRTFTNVYWMKVND                                         211 - 243

Text Mined References (15)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24675470 2014 Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers.
23815882 2013 Overexpression of peptide deformylase in breast, colon, and lung cancers.
22554513 2012 Transcriptional regulation of the human mitochondrial peptide deformylase (PDF).
21805148 2012 Successful COG8 and PDF overlap is mediated by alterations in splicing and polyadenylation signals.
19236878 2009 Structure and activity of human mitochondrial peptide deformylase, a novel cancer target.
19064571 2008 Polymorphisms in mitochondrial genes and prostate cancer risk.
15489958 2004 Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14637138 2003 A new human peptide deformylase inhibitable by actinonin.
14532271 2003 An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway.
12924944 2003 Characterization of a human peptide deformylase: implications for antibacterial drug design.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12417987 2002 A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.
11060042 2000 Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms.