| Tbio | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Obesity | 678 | 3.118 | 1.6 |
| Carcinoma, Hepatocellular | 228 | 0.0 | 0.0 |
| Diabetes Mellitus, Experimental | 108 | 0.0 | 0.0 |
| Heart failure | 162 | 0.0 | 0.0 |
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Phosphoenolpyruvate carboxykinase deficiency | 2 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 7.2e-19 |
| pituitary cancer | 1972 | 3.5e-16 |
| ulcerative colitis | 1819 | 6.3e-08 |
| lung cancer | 4740 | 9.8e-07 |
| psoriasis | 6694 | 1.2e-05 |
| invasive ductal carcinoma | 2951 | 2.5e-04 |
| ductal carcinoma in situ | 1745 | 2.7e-04 |
| breast carcinoma | 1638 | 4.7e-03 |
| colon cancer | 1478 | 5.9e-03 |
| nephrosclerosis | 333 | 1.2e-02 |
| Atopic dermatitis | 952 | 1.2e-02 |
| autosomal dominant Emery-Dreifuss muscular dystrophy | 510 | 1.2e-02 |
| fibroadenoma | 559 | 3.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| diabetes mellitus | 1728 | 4.101 | 2.1 |
| Hyperglycemia | 137 | 3.7 | 1.9 |
| Hypotrichosis 8 | 6 | 3.463 | 1.7 |
| Fatty liver disease | 103 | 3.232 | 1.6 |
| Lactic acidosis | 51 | 3.17 | 1.6 |
| Disease | Target Count |
|---|---|
| Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | 1 |
| Disease | log2 FC | p |
|---|---|---|
| Atopic dermatitis | -2.100 | 1.2e-02 |
| autosomal dominant Emery-Dreifuss muscul... | 1.129 | 1.2e-02 |
| breast carcinoma | -1.800 | 4.7e-03 |
| colon cancer | -1.900 | 5.9e-03 |
| ductal carcinoma in situ | -4.300 | 2.7e-04 |
| fibroadenoma | -2.300 | 3.8e-02 |
| invasive ductal carcinoma | -5.300 | 2.5e-04 |
| lung cancer | 5.300 | 9.8e-07 |
| lung carcinoma | 4.100 | 7.2e-19 |
| nephrosclerosis | -2.161 | 1.2e-02 |
| pituitary cancer | -6.400 | 3.5e-16 |
| psoriasis | -1.400 | 1.2e-05 |
| ulcerative colitis | -5.200 | 6.3e-08 |
MPPQLQNGLNLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQMEEEGILRRLK 1 - 70 KYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMY 71 - 140 VIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGTPVLEAVGDGEFVKCLHSVGCPLPLQKPLVNNW 141 - 210 PCNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHMLILGITNPEGEKKYL 211 - 280 AAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKT 281 - 350 IQKNTIFTNVAETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAW 351 - 420 ESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKIIMHDPFAMRPFFGYNF 421 - 490 GKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVLEWMFNRIDGKASTKLTPIGYIPK 491 - 560 EDALNLKGLGHINMMELFSISKEFWEKEVEDIEKYLEDQVNADLPCEIEREILALKQRISQM 561 - 622 //
