Tbio PCGF6 Polycomb group RING finger protein 6

Protein Summary

Description

Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BYE7
• A8K3R4
• Q5SYD1
• Q5SYD6
• Q96ID9
• Q96SJ1

Gene Name

• PCGF6

Ensembl ID

• ENST00000337211
• ENSP00000338845
• ENSG00000156374
• ENST00000369847
• ENSP00000358862

Symbol

• MBLR
• RNF134
• MBLR
• RNF134

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
molecular function	0.79
protein domain	0.73
transcription factor perturbation	0.68
tissue sample	0.66

Protein Classes

PANTHER Classes

Protein / ... / Ubiquitin-protein Ligase / Polycomb Group Ring Finger Protein 6

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Polycomb Group Ring Finger Protein 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.65   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.65   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0