Tchem PBK Lymphokine-activated killer T-cell-originated protein kinase

Protein Summary

Description

Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q96KB5
• B4DX68
• D3DST2
• Q9NPD9
• Q9NYL7
• Q9NZK6

Gene Name

• PBK

Ensembl ID

• ENST00000301905
• ENSP00000301905
• ENSG00000168078
• ENST00000522944
• ENSP00000428489

Symbol

• TOPK
• SPK
• CT84
• TOPK
• HEL164
• Nori-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
molecular function	0.91
histone modification site profile	0.88
biological process	0.76
gene perturbation	0.75

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Lymphokine-activated Killer T-cell-originated Protein Kinase

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Topk Family / Lymphokine-activated Killer T-cell-originated Protein Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 519.07   (req: < 5)

Gene RIFs: 87   (req: <= 3)

Antibodies: 512   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 519.07   (req: >= 5)

Gene RIFs: 87   (req: > 3)

Antibodies: 512   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0