Tbio PARPBP PCNA-interacting partner

Protein Summary

Description

Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.

Uniprot Accession IDs

• Q9NWS1
• B4E0Y0
• Q05C00
• Q499L8
• Q4FZA0
• Q4KMW7
• Q6NSC6
• Q6PJA1
• Q86W36
• PARI

Gene Name

• PARPBP

Ensembl ID

• ENST00000327680
• ENSP00000332915
• ENSG00000185480
• ENST00000392911
• ENSP00000376643
• ENST00000537257
• ENSP00000442549

Symbol

• C12orf48
• PARI
• AROM
• PARI
• C12orf48

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
transcription factor binding site profile	0.64
microRNA	0.59
cell type or tissue	0.51
tissue	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.88   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 80   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.88   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0