Tdark PAQR9 Membrane progestin receptor epsilon

Protein Summary

Description

Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).

Uniprot Accession IDs

• Q6ZVX9
• Q147T6
• mPR epsilon

Gene Name

• PAQR9

Ensembl ID

• ENST00000340634
• ENSP00000341564
• ENSG00000188582

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.79
microRNA	0.65
PubMedID	0.58
cell type or tissue	0.56
transcription factor binding site profile	0.55

Protein Classes

PANTHER Classes

Protein / Receptor / Membrane Progestin Receptor Epsilon

DTO Classes

Protein / Receptor / Membrane Progestin Receptor Epsilon

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.32   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 7   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.32   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0