| Tbio | Membrane progestin receptor beta |
Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| group 3 medulloblastoma | 4104 | 1.1e-06 |
| hepatocellular carcinoma | 547 | 8.3e-06 |
| medulloblastoma, large-cell | 6241 | 1.2e-05 |
| ependymoma | 4679 | 1.2e-05 |
| Astrocytoma, Pilocytic | 3081 | 6.2e-05 |
| pituitary cancer | 1972 | 1.7e-04 |
| adult high grade glioma | 3801 | 1.8e-04 |
| glioblastoma | 5792 | 2.0e-04 |
| head and neck cancer | 271 | 2.6e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 4.2e-04 |
| ulcerative colitis | 1819 | 6.1e-04 |
| pancreatic cancer | 2398 | 9.2e-04 |
| interstitial cystitis | 2312 | 1.6e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.0e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 9.4e-03 |
| urothelial carcinoma | 318 | 1.2e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.8e-02 |
| primitive neuroectodermal tumor | 3035 | 1.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Epilepsy with generalized tonic-clonic seizures | 5 | 4.354 | 2.2 |
| Juvenile myoclonic epilepsy | 21 | 4.306 | 2.2 |
| Bronchopneumonia | 3 | 3.125 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.300 | 1.8e-04 |
| Astrocytoma, Pilocytic | -1.200 | 6.2e-05 |
| atypical teratoid / rhabdoid tumor | -1.100 | 9.4e-03 |
| ependymoma | -1.600 | 1.2e-05 |
| glioblastoma | -1.100 | 2.0e-04 |
| group 3 medulloblastoma | -2.300 | 1.1e-06 |
| head and neck cancer | -1.300 | 2.6e-04 |
| hepatocellular carcinoma | 1.200 | 8.3e-06 |
| interstitial cystitis | -1.100 | 1.6e-03 |
| intraductal papillary-mucinous adenoma (... | 2.800 | 4.2e-04 |
| intraductal papillary-mucinous carcinoma... | 2.400 | 3.0e-03 |
| intraductal papillary-mucinous neoplasm ... | 2.500 | 1.8e-02 |
| medulloblastoma, large-cell | -2.100 | 1.2e-05 |
| pancreatic cancer | 1.200 | 9.2e-04 |
| pituitary cancer | 1.300 | 1.7e-04 |
| primitive neuroectodermal tumor | -1.100 | 1.8e-02 |
| ulcerative colitis | -1.200 | 6.1e-04 |
| urothelial carcinoma | -1.800 | 1.2e-02 |
MTTAILERLSTLSVSGQQLRRLPKILEDGLPKMPCTVPETDVPQLFREPYIRTGYRPTGHEWRYYFFSLF 1 - 70 QKHNEVVNVWTHLLAALAVLLRFWAFAEAEALPWASTHSLPLLLFILSSITYLTCSLLAHLLQSKSELSH 71 - 140 YTFYFVDYVGVSVYQYGSALAHFFYSSDQAWYDRFWLFFLPAAAFCGWLSCAGCCYAKYRYRRPYPVMRK 141 - 210 ICQVVPAGLAFILDISPVAHRVALCHLAGCQEQAAWYHTLQILFFLVSAYFFSCPVPEKYFPGSCDIVGH 211 - 280 GHQIFHAFLSICTLSQLEAILLDYQGRQEIFLQRHGPLSVHMACLSFFFLAACSAATAALLRHKVKARLT 281 - 350 KKDS 351 - 354 //
