Tbio PABPC3 Polyadenylate-binding protein 3

Protein Summary

Description

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1. Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002]

Uniprot Accession IDs

• Q9H361
• Q8NHV0
• Q9H086
• PABP-3

Gene Name

• PABPC3

Ensembl ID

• ENST00000281589
• ENSP00000281589
• ENSG00000151846

Symbol

• PABP3
• PABPL3
• PABP3
• tPABP
• PABPL3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.9
cell type or tissue	0.76
protein domain	0.58
cell line	0.54
protein complex	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.09   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.09   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0