ARHGAP4
Rho GTPase-activating protein 4
Protein Summary
Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
- ENST00000350060
- ENSP00000203786
- ENSG00000089820
- ENST00000370028
- ENSP00000359045
- KIAA0131
- RGC1
- RHOGAP4
- C1
- RGC1
- p115
- SrGAP4
- RhoGAP4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.91 | ||
biological process | 0.71 | ||
gene perturbation | 0.7 | ||
tissue sample | 0.69 | ||
molecular function | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.67 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 100 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.67 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 100 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0