| Tbio | Chromobox protein homolog 1 |
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Prostatic Neoplasms | 495 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 5.8e-19 |
| group 3 medulloblastoma | 4104 | 3.9e-05 |
| lung cancer | 4740 | 1.3e-04 |
| dermatomyositis | 966 | 1.5e-04 |
| ovarian cancer | 8520 | 2.8e-04 |
| Waldenstrons macroglobulinemia | 765 | 1.3e-02 |
| primary pancreatic ductal adenocarcinoma | 1109 | 1.8e-02 |
| Disease | log2 FC | p |
|---|---|---|
| dermatomyositis | 1.400 | 1.5e-04 |
| group 3 medulloblastoma | 1.700 | 3.9e-05 |
| lung cancer | 1.300 | 1.3e-04 |
| non-small cell lung cancer | 1.094 | 5.8e-19 |
| ovarian cancer | -1.600 | 2.8e-04 |
| primary pancreatic ductal adenocarcinoma | 1.134 | 1.8e-02 |
| Waldenstrons macroglobulinemia | 1.035 | 1.3e-02 |
