| Tbio | Chromobox protein homolog 1 |
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| NCBI Gene PubMed Count | 67 |
| Grant Count | 9 |
| R01 Count | 4 |
| Funding | $3,905,078.72 |
| PubMed Score | 197.03 |
| PubTator Score | 104.31 |
| Disease | log2 FC | p |
|---|---|---|
| Waldenstrons macroglobulinemia | 1.035 | 0.013 |
| group 3 medulloblastoma | 1.700 | 0.000 |
| primary pancreatic ductal adenocarcinoma | 1.134 | 0.018 |
| non-small cell lung cancer | 1.094 | 0.000 |
| lung cancer | 1.300 | 0.000 |
| ovarian cancer | -1.600 | 0.000 |
| dermatomyositis | 1.400 | 0.000 |
| AID | Type | Active / Inconclusive / Inactive | Description |
|---|---|---|---|
| 488953 | confirmatory |
186 / 277 / 817 | qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails |
| 488962 | summary |
0 / 0 / 0 | Probe Summary Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails |
| 540317 | confirmatory |
2150 / 13416 / 371468 | HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails |
| PMID | Text |
|---|---|
| 27090491 | Data show that heterochromatin protein 1-beta (HP1beta) is a prototypic HP1 protein exemplifying most basal chromatin binding and effects. |
| 25769025 | increased HP1beta expression is associated with the poor prognosis in breast cancer |
| 24840329 | Data suggest the reduction of Heterochromatin Protein 1 isoforms HP1beta followed by a decrease in HP1alpha contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively. |
| 24793759 | In this review, we summarize the current knowledge about targeting and functional mechanisms of PRCs, emphasizing the recent breakthroughs related to CBX proteins under a number of physiological and pathological conditions. |
| 24561199 | Phosphorylation at Ser89 and Ser175 results in localized conformational changes in HP1beta that do not compromise the ability of the protein to bind chromatin. |
| 23707759 | The HP1beta interactome is enriched with Lys methylated proteins.Role of HP1beta in DNA damage response. |
| 23585859 | The structural plasticity of HP1beta supports its ability to bind and connect a wide variety of binding partners in epigenetic processes. |
| 23536649 | HP1 isoforms distinctly augment AR signaling and cell growth in prostate cancer. Therefore, silencing of HP1beta and HP1gamma may be a promising therapeutic strategy for treatment of prostate cancer. |
| 23337132 | HP1beta which is associated with PCNA in regions of DNA repair, is bound and does not exchange with the mobile pool, suggesting that HP1beta in association with PCNA may be a component of a DNA repair complex. |
| 23287531 | study finds that while HP1apha and beta stimulate homologous recombination and single-strand annealing, HP1gamma has an inhibitory role |
| More... |
| PMID | Year | Title |
|---|---|---|
| 27090491 | 2016 | Dynamic and flexible H3K9me3 bridging via HP1? dimerization establishes a plastic state of condensed chromatin. |
| 25769025 | 2015 | HP1? is a biomarker for breast cancer prognosis and PARP inhibitor therapy. |
| 25755297 | 2015 | System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability. |
| 24840329 | 2014 | Heterochromatin protein 1 expression is reduced in human thyroid malignancy. |
| 24793759 | 2014 | Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins. |
| 24561199 | 2014 | Characterization of the effects of phosphorylation by CK2 on the structure and binding properties of human HP1?. |
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
| 24270157 | 2013 | A quantitative telomeric chromatin isolation protocol identifies different telomeric states. |
| 23707759 | 2013 | A method for systematic mapping of protein lysine methylation identifies functions for HP1? in DNA damage response. |
| 23585859 | 2013 | Structural plasticity in human heterochromatin protein 1?. |
| More... |
