| Tdark | 28S ribosomal protein S35, mitochondrial |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 3.8e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 5.4e-03 |
| lung cancer | 4740 | 8.0e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.6e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.3e-02 |
| esophageal adenocarcinoma | 737 | 4.0e-02 |
| Disease | log2 FC | p |
|---|---|---|
| esophageal adenocarcinoma | 1.100 | 4.0e-02 |
| intraductal papillary-mucinous adenoma (... | 1.200 | 5.4e-03 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 1.6e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.200 | 3.3e-02 |
| lung cancer | 1.100 | 8.0e-03 |
| ovarian cancer | 1.800 | 3.8e-04 |
MAAAALPAWLSLQSRARTLRAFSTAVYSATPVPTPSLPERTPGNERPPRRKALPPRTEKMAVDQDWPSVY 1 - 70 PVAAPFKPSAVPLPVRMGYPVKKGVPMAKEGNLELLKIPNFLHLTPVAIKKHCEALKDFCTEWPAALDSD 71 - 140 EKCEKHFPIEIDSTDYVSSGPSVRNPRARVVVLRVKLSSLNLDDHAKKKLIKLVGERYCKTTDVLTIKTD 141 - 210 RCPLRRQNYDYAVYLLTVLYHESWNTEEWEKSKTEADMEEYIWENSSSERNILETLLQMKAAEKNMEINK 211 - 280 EELLGTKEIEEYKKSVVSLKNEEENENSISQYKESVKRLLNVT 281 - 323 //
