Property Summary

NCBI Gene PubMed Count 113
Grant Count 48
R01 Count 21
Funding $6,743,192.88
PubMed Score 172.55
PubTator Score 259.69

Knowledge Summary

Patent

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Gene RIF (105)

PMID Text
26733497 epidermal growth factor receptor (EGFR)activation via phosphorylation of EGFR via TAK1-p38alpha pathway, and subsequent internalization of EGFR are functionally linked to the induction of hBD3 in gastric epithelial cells infected with H. pylori.
26688341 These results demonstrate that the gamma-core within HBD3 is the ancestral core of the full-length molecule and is a viable HDP per se, since it is endowed with the most important biological features of HBD3
26646717 Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 suppresses the polyI:C-induced TLR3 response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1) and MAVS (IPS1/CARDIF).
26539799 HBD2 or HBD3 cointernalized with virions in endosomes, formed oligomers, and reduced infectivity of human immunodeficiency virus.
26536271 Study found that HBD2 bound tightly to Mc1r with an affinity similar to that of HBD3
26417692 M. catarrhalis induced hBD-3 expression in pulmonary epithelial cells, which was dependent on M. catarrhalis membranous lipoolygosaccharide.
26347021 C-terminal 15-mer peptide within hBD3, designated as hBD3-3, has cell- and skin-penetrating activity, which can induce anti-inflammatory activity
26302933 TLR1, TLR2 and CCR2 were expressed on NK cells, and in NK culture experiments we observed hBD-3 to directly act on NK cells, resulting in CD69 upregulation and IFNgamma secretion. We also observed mDC-hBD-3 enhanced NK cytolytic activity and IFNgamma production.
26224324 the role of DEFB103 gene copy number variation (CNV) in ankylosing spondylitis (AS) susceptibility, was investigated.
26038828 there is a significant link between innate immunity deregulation through disruption of cationic peptides (hBDs) and the potential development of colon cancer.
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AA Sequence

MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK         1 - 67
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Text Mined References (113)

PMID Year Title
26733497 2016 Novel epidermal growth factor receptor pathway mediates release of human ?-defensin 3 from Helicobacter pylori-infected gastric epithelial cells.
26688341 2015 An ancestral host defence peptide within human ?-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule.
26646717 2015 Human ?-Defensin 3 [corrected] Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.
26539799 2016 Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells.
26536271 2015 Electrostatic Similarity Analysis of Human ?-Defensin Binding in the Melanocortin System.
26417692 2015 The role and regulation of Moraxella catarrhalis-induced human beta-defensin 3 expression in human pulmonary epithelial cells.
26367466 2015 Cytotoxicity of HBD3 for dendritic cells, normal human epidermal keratinocytes, hTERT keratinocytes, and primary oral gingival epithelial keratinocytes in cell culture conditions.
26347021 2015 Identification of a cell-penetrating peptide domain from human beta-defensin 3 and characterization of its anti-inflammatory activity.
26302933 2015 HBD-3 induces NK cell activation, IFN-? secretion and mDC dependent cytolytic function.
26224324 2015 Association between DEFB103 gene copy number variation and ankylosing spondylitis: a case-control study.
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