1. Home
  2. Targets
  3. calcium-binding protein
  4. annexin
  5. calmodulin
  6. Nucleobindin-2

Tbio Nucleobindin-2

Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance (By similarity).

This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

 Comments

Property Summary

NCBI Gene PubMed Count 98
PubMed Score 120.29
PubTator Score 171.85

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Prostatic Neoplasms 495 0.0 0.0
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.7
Disease Target Count Z-score Confidence
Obesity 678 3.662 1.8

Expression

  Differential Expression (25)

Disease log2 FC p
active Crohn's disease 2.219 1.5e-03
Amyotrophic lateral sclerosis 1.408 1.2e-06
colon cancer -1.100 1.7e-02
diabetes mellitus -1.100 2.9e-02
ependymoma 1.100 2.7e-08
gastric carcinoma -1.500 3.4e-02
glioblastoma 1.100 2.5e-03
group 3 medulloblastoma 1.300 3.0e-04
intraductal papillary-mucinous adenoma (... -1.500 6.8e-03
intraductal papillary-mucinous carcinoma... -1.900 8.3e-03
intraductal papillary-mucinous neoplasm ... -3.000 1.2e-03
lung cancer -1.800 8.7e-04
malignant mesothelioma -1.400 3.8e-07
nasopharyngeal carcinoma -1.400 7.0e-05
nephrosclerosis 1.095 2.6e-04
osteosarcoma -1.886 6.2e-03
ovarian cancer -1.200 1.3e-02
pancreatic cancer -1.400 7.0e-04
pancreatic ductal adenocarcinoma liver m... -2.080 2.6e-04
Pneumonia -1.400 9.7e-03
progressive supranuclear palsy -1.300 9.9e-03
psoriasis -1.200 2.7e-03
subependymal giant cell astrocytoma 2.254 4.5e-02
ulcerative colitis 1.900 8.2e-08
Waldenstrons macroglobulinemia 1.405 2.6e-02

Synonym

Accession P80303 A8K642 D3DQX5 Q8NFT5
Symbols NEFA
HEL-S-109

Gene

NUCB2

PANTHER Protein Class (3)

  Ortholog (15)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
OMA EggNOG
Inparanoid OMA
Inparanoid EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (18)

See all...

 GO Function (2)

 GO Component (8)

 Compartment GO Term (27)

See all...

 MGI Phenotype (2)

 GWAS Trait (5)

 HCA RNA Cell Line (56)

See all...

Gene RIF (83)

AA Sequence 

MRWRTILLQYCFLLITCLLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKH      1 - 70
FREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQFD     71 - 140
HLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEM    141 - 210
KKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDP    211 - 280
KNEEDDMVEMEEERLRMREHVMSEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEY    281 - 350
ENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQGIPPSGPAGELKFEPHI    351 - 420
//

Text Mined References (104)

PMID Year Title