| Tbio | Nucleobindin-2 |
Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance (By similarity).
This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]
This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Prostatic Neoplasms | 495 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ependymoma | 4679 | 2.7e-08 |
| ulcerative colitis | 1819 | 8.2e-08 |
| malignant mesothelioma | 3232 | 3.8e-07 |
| Amyotrophic lateral sclerosis | 451 | 1.2e-06 |
| nasopharyngeal carcinoma | 1058 | 7.0e-05 |
| nephrosclerosis | 333 | 2.6e-04 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.6e-04 |
| group 3 medulloblastoma | 4104 | 3.0e-04 |
| pancreatic cancer | 2398 | 7.0e-04 |
| lung cancer | 4740 | 8.7e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.2e-03 |
| active Crohn's disease | 922 | 1.5e-03 |
| glioblastoma | 5792 | 2.5e-03 |
| psoriasis | 6694 | 2.7e-03 |
| osteosarcoma | 7950 | 6.2e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 6.8e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 8.3e-03 |
| Pneumonia | 174 | 9.7e-03 |
| progressive supranuclear palsy | 676 | 9.9e-03 |
| ovarian cancer | 8520 | 1.3e-02 |
| colon cancer | 1478 | 1.7e-02 |
| Waldenstrons macroglobulinemia | 765 | 2.6e-02 |
| diabetes mellitus | 1728 | 2.9e-02 |
| gastric carcinoma | 807 | 3.4e-02 |
| subependymal giant cell astrocytoma | 2287 | 4.5e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | 2.219 | 1.5e-03 |
| Amyotrophic lateral sclerosis | 1.408 | 1.2e-06 |
| colon cancer | -1.100 | 1.7e-02 |
| diabetes mellitus | -1.100 | 2.9e-02 |
| ependymoma | 1.100 | 2.7e-08 |
| gastric carcinoma | -1.500 | 3.4e-02 |
| glioblastoma | 1.100 | 2.5e-03 |
| group 3 medulloblastoma | 1.300 | 3.0e-04 |
| intraductal papillary-mucinous adenoma (... | -1.500 | 6.8e-03 |
| intraductal papillary-mucinous carcinoma... | -1.900 | 8.3e-03 |
| intraductal papillary-mucinous neoplasm ... | -3.000 | 1.2e-03 |
| lung cancer | -1.800 | 8.7e-04 |
| malignant mesothelioma | -1.400 | 3.8e-07 |
| nasopharyngeal carcinoma | -1.400 | 7.0e-05 |
| nephrosclerosis | 1.095 | 2.6e-04 |
| osteosarcoma | -1.886 | 6.2e-03 |
| ovarian cancer | -1.200 | 1.3e-02 |
| pancreatic cancer | -1.400 | 7.0e-04 |
| pancreatic ductal adenocarcinoma liver m... | -2.080 | 2.6e-04 |
| Pneumonia | -1.400 | 9.7e-03 |
| progressive supranuclear palsy | -1.300 | 9.9e-03 |
| psoriasis | -1.200 | 2.7e-03 |
| subependymal giant cell astrocytoma | 2.254 | 4.5e-02 |
| ulcerative colitis | 1.900 | 8.2e-08 |
| Waldenstrons macroglobulinemia | 1.405 | 2.6e-02 |
MRWRTILLQYCFLLITCLLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKH 1 - 70 FREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQFD 71 - 140 HLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEM 141 - 210 KKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDP 211 - 280 KNEEDDMVEMEEERLRMREHVMSEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEY 281 - 350 ENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQGIPPSGPAGELKFEPHI 351 - 420 //
