Property Summary

NCBI Gene PubMed Count 21
PubMed Score 29.17
PubTator Score 15.79

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
non-small cell lung cancer 2798 2.94026882125444E-11
acute quadriplegic myopathy 1157 8.41140864148665E-9
ulcerative colitis 2087 1.16619980878035E-7
ovarian cancer 8492 7.5089307596652E-7
lung cancer 4473 7.84866743194892E-7
malignant mesothelioma 3163 2.19276707086527E-6
colon cancer 1475 1.23202262698077E-5
lung carcinoma 2844 1.29291217783692E-5
atypical teratoid/rhabdoid tumor 1095 2.38288011415648E-5
Breast cancer 3099 3.93091872146483E-5
osteosarcoma 7933 4.13158662722727E-5
group 3 medulloblastoma 2254 5.67064090560218E-5
cystic fibrosis 1670 2.74009531325151E-4
medulloblastoma, large-cell 6234 5.563001173224E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0042823702360464
primary pancreatic ductal adenocarcinoma 1271 0.00480109087827544
pancreatic cancer 2300 0.00690596297948191
cutaneous lupus erythematosus 1056 0.00794966496437746
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0101301346288973
Endometriosis 535 0.0238872672229026
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0279352511798144
active Crohn's disease 918 0.0314405452142368



Accession P80294 B2RUY6 MT-1H
Symbols MT1


  Ortholog (1)

Species Source
Chimp OMA EggNOG

Gene RIF (5)

24662736 MT1H was down-regulated in renal cell carcinogenesis.
20551211 Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia.
15747776 Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Heavy metal binding activity.
12539042 Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection
12081484 S-nitrosothiols react preferentially with zinc thiolate clusters through transnitrosation.

AA Sequence


Text Mined References (21)

PMID Year Title
24662736 2015 An epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis.
22780124 2013 Genome-wide association study of a quantitative disordered gambling trait.
20551211 2010 Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.
16827180 2006 Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes.
15747776 2003 Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14668352 2004 The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity.
12970870 2003 Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene.
12646258 2003 ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis.
12539042 2003 HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.