Tbio CXCL6 C-X-C motif chemokine 6

Protein Summary

Description

Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).

Uniprot Accession IDs

• P80162
• B2R4X3
• Q4W5D4

Gene Name

• CXCL6

Ensembl ID

• ENST00000226317
• ENSP00000226317
• ENSG00000124875

Symbol

• GCP2
• SCYB6
• GCP2
• CKA-3
• GCP-2
• SCYB6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.77
disease	0.6
kinase perturbation	0.6
biological process	0.57
molecular function	0.56

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / C-x-c Motif Chemokine 6

DTO Classes

Protein / Signaling / Chemokine / C-x-c Motif Chemokine 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.25   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.25   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0