Property Summary

NCBI Gene PubMed Count 84
Grant Count 1,749
R01 Count 90
Funding $565,394,874.25
PubMed Score 994.33
PubTator Score 292.95

Knowledge Summary

Patent

No data available

Synonym

Accession P80098 Q569J6
Symbols FIC
MARC
MCP3
NC28
MCP-3
SCYA6
SCYA7

Gene

PDB

1BO0   1NCV   4ZKC  

Gene RIF (53)

PMID Text
26756352 Periprostatic adipocytes drive prostate cancer progression in obesity via CCL7 secretion which stimulates CCR3 expressing tumor cells.
25261323 Based on nasopharyngeal CCL7 gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants.
25193015 These results suggest that let-7d may suppress renal cell carcinoma growth, metastasis, and tumor macrophage infiltration at least partially through targeting COL3A1 and CCL7.
24742347 HIV-1 and the viral protein Tat modulate the expression of chemokine (C-C motif) ligand 7 (CCL7; MCP-3) in immature dendritic cells and monocyte-derived macrophages
24742347 HIV-1 and the viral protein Tat modulate the expression of chemokine (C-C motif) ligand 7 (CCL7; MCP-3) in immature dendritic cells and monocyte-derived macrophages
24727473 Data indicate that different glycosaminoglycan-binding properties of monocyte chemoattractant protein-3/CCL7 and monocyte chemoattractant protein (MCP)-1/CCL2 suggest non-redundant functions and regulation.
24578274 Overexpression of ISL1 in human mesnchymal stem cells promotes angiogenesis in vitro and in vivo through increasing secretion of MCP3 and other paracrine factors.
24327013 Our data demonstrate that the monocyte-specific chemokine CCL7 and its receptor CCR2 are expressed in tumour cells of RCC
23764760 Anticancer effect of desmethyl-lasiodiplodin is mediated, in part, by upregulation of apoptotic genes and downregulation of MCP-3.
23762028 Systemic IFN-gamma triggered the secretion of C-C motif ligand chemokines CCL2 and CCL7 leading to the egress of early, myeloid-committed progenitors from the bone marrow mediated by their common receptor CCR2.
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AA Sequence

MKASAALLCLLLTAAAFSPQGLAQPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKL      1 - 70
DKEICADPTQKWVQDFMKHLDKKTQTPKL                                              71 - 99
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Text Mined References (84)

PMID Year Title
26756352 2016 Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity.
25416956 2014 A proteome-scale map of the human interactome network.
25261323 2015 Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection.
25193015 2014 Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7.
24727473 2014 Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7 enable it to function as a non-oligomerizing chemokine.
24578274 2014 Islet-1 overexpression in human mesenchymal stem cells promotes vascularization through monocyte chemoattractant protein-3.
24327013 2014 Brain metastasis in renal cancer patients: metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression.
23764760 2013 Apoptosis induced by desmethyl-lasiodiplodin is associated with upregulation of apoptotic genes and downregulation of monocyte chemotactic protein-3.
23762028 2013 Extramedullary myelopoiesis in malaria depends on mobilization of myeloid-restricted progenitors by IFN-? induced chemokines.
22614322 2012 CC chemokine ligand 7 expression in liver metastasis of colorectal cancer.
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