Property Summary

NCBI Gene PubMed Count 175
PubMed Score 1140.07
PubTator Score 375.79

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
tuberculosis 1563 2.27033999842391E-9
malignant mesothelioma 3163 6.13901344688403E-9
head and neck cancer 270 7.02567987894685E-9
lung cancer 4473 8.26507943326073E-7
pancreatic cancer 2300 1.25690885886239E-5
urothelial carcinoma 318 4.957043162398E-5
posterior fossa group A ependymoma 1511 7.27435620309453E-5
ovarian cancer 8492 1.56054222769454E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 3.35697807046937E-4
primary Sjogren syndrome 789 9.61610876666443E-4
lung carcinoma 2844 0.00197189443540313
non-small cell lung cancer 2798 0.00598165295403918
pediatric high grade glioma 2712 0.00892934069238026
active ulcerative colitis 477 0.00970320904537235
cutaneous lupus erythematosus 1056 0.0155391498690167
lung adenocarcinoma 2714 0.0187953066918676
esophageal adenocarcinoma 737 0.019724534382555
active Crohn's disease 918 0.021131553715651
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0247512183717082
glioblastoma 5572 0.0273175208688361
Barrett's esophagus 185 0.0276528171006661
cystic fibrosis 1670 0.0325952384561383
interstitial cystitis 2299 0.0415099906145293
Bipolar Disorder 266 0.0461691759094986



Accession P78556 Q53S51 Q99664
Symbols CKb4



1M8A   2HCI   2JYO  

  Ortholog (11)

Gene RIF (151)

26634210 Both MIP-3alpha and cystatin A overexpressions in NPC tumor tissues were strong independent factors of poor prognosis in NPC patients.
26536229 High CCL20 expression is associated with Inflammatory Bowel Disease.
26448160 human lung epithelial cells secrete CCL20 and BD2 in response to B. abortus and/or to cytokines produced by infected monocytes.
26400278 High-risk HPV-type lesions might inhibit the chemokine CCL20 on Langerhans cells through E6 and E7 to escape the immune response.
26345847 Tregs of unexplained recurrent miscarriage patients was significantly lower than that in controls. CCL20-CCR6 could drive immune activity of CD4(+)FOXP3(+) Tregs, followed by their migration to the feto-maternal microenvironment
26296735 ADAM10 activity contributes to house dust mite-induced shedding of chemokines, including CCL20
26284335 CCL4 and CCL20 recruit functionally different T lymphocyte subsets into oesophageal carcinoma.
26156805 AEG-1 mediates CCL20/CCR6-induced EMT development via both Erk1/2 and Akt signaling pathway in cervical cancer, which indicates that CCL20/CCR6-AEG-1-EMT pathway could be suggested as a useful target to affect the progression of cervical cancer.
26125463 stimulates leukocyte migration in ovary, may aid in final ovulatory events
26116899 HIV-1 Vpr downregulates the expression of CCL20 in human monocyte-derived dendritic cells

AA Sequence

LSVCANPKQTWVKYIVRLLSKKVKNM                                                 71 - 96

Text Mined References (176)

PMID Year Title
26634210 2015 Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma.
26536229 2015 Expression of CCL20 and Its Corresponding Receptor CCR6 Is Enhanced in Active Inflammatory Bowel Disease, and TLR3 Mediates CCL20 Expression in Colonic Epithelial Cells.
26448160 2015 CCL20 and Beta-Defensin 2 Production by Human Lung Epithelial Cells and Macrophages in Response to Brucella abortus Infection.
26400278 2015 Correlation of E6 and E7 levels in high-risk HPV16 type cervical lesions with CCL20 and Langerhans cells.
26345847 2015 Regulation of CD4?FOXP3? T cells by CCL20/CCR6 axis in early unexplained recurrent miscarriage patients.
26296735 2015 ADAM10 mediates the house dust mite-induced release of chemokine ligand CCL20 by airway epithelium.
26284335 2015 CTL- vs Treg lymphocyte-attracting chemokines, CCL4 and CCL20, are strong reciprocal predictive markers for survival of patients with oesophageal squamous cell carcinoma.
26156805 2015 The key role of astrocyte elevated gene-1 in CCR6-induced EMT in cervical cancer.
26125463 2015 Chemokine Ligand 20: A Signal for Leukocyte Recruitment During Human Ovulation?
26103626 2015 CXCL8 and CCL20 Enhance Osteoclastogenesis via Modulation of Cytokine Production by Human Primary Osteoblasts.