GSTO1
Glutathione S-transferase omega-1
Protein Summary
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
- ENST00000369710
- ENSP00000358724
- ENSG00000148834
- ENST00000369713
- ENSP00000358727
- ENST00000539281
- ENSP00000441488
- GSTTLP28
- P28
- SPG-R
- GSTO 1-1
- GSTTLp28
- HEL-S-21
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
transcription factor perturbation | 1 | ||
kinase perturbation | 0.99 | ||
biological process | 0.79 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159.96 (req: < 5)
Gene RIFs: 76 (req: <= 3)
Antibodies: 263 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159.96 (req: >= 5)
Gene RIFs: 76 (req: > 3)
Antibodies: 263 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 54
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1