Property Summary

NCBI Gene PubMed Count 27
PubMed Score 20.77
PubTator Score 18.05

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
periodontitis 269 2.25148441179823E-23
nasopharyngeal carcinoma 1056 2.3271856733512E-10
medulloblastoma 1524 3.6914359038404E-10
non-small cell lung cancer 2798 7.41968683785374E-8
medulloblastoma, large-cell 6234 1.89363413496069E-7
pediatric high grade glioma 2712 1.70422190306088E-5
ovarian cancer 8492 3.859455938767E-5
glioblastoma 5572 8.97063790382864E-5
primitive neuroectodermal tumor 3031 2.12609933002616E-4
lung adenocarcinoma 2714 2.95175494247195E-4
psoriasis 6685 3.70321825537523E-4
Breast cancer 3099 5.06368757665622E-4
Down syndrome 548 0.00192285620560767
atypical teratoid / rhabdoid tumor 4369 0.00203187284758729
head and neck cancer and chronic obstructive pulmonary disease 237 0.00270484722104005
astrocytic glioma 2241 0.00275742474495747
pancreatic cancer 2300 0.00344410465407697
subependymal giant cell astrocytoma 2287 0.00567071817935293
oligodendroglioma 2849 0.00673503246515655
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00779110095337796
primary pancreatic ductal adenocarcinoma 1271 0.00790157791820557
lung cancer 4473 0.00881846577114799
mucosa-associated lymphoid tissue lymphoma 480 0.0112655369733149
acute myeloid leukemia 785 0.0130076818341792
osteosarcoma 7933 0.0131780145022389
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0154063235056068
severe Alzheimer's disease 49 0.0179713816589585
nephrosclerosis 329 0.0190840350200032
ependymoma 2514 0.0256641007144619
Disease Target Count Z-score Confidence
Biphasic synovial sarcoma 2 3.249 1.6



Accession P78369 Q6IBF9 Q96N78
Symbols OSP-L


PANTHER Protein Class (2)

  Ortholog (12)

 GWAS Trait (1)

Gene RIF (13)

26340953 localization of Cldn3, Cldn7 and Cldn10 proteins in the different compartments of murine endometrium up to day 8.5 of pregnancy (dpc) as well as in human endometrium and first trimester decidua
25867809 An algorithm combining CLDN10, HMGA2, and LAMB3 transcripts was able to discriminate tumors from BTL samples (94% sensitivity and 96% specificity in validation set).
24325792 Claudin 10 expression was down-regulated in gastric cancer.
23760508 In claudin-10b, the F66L mutant reduced cation selectivity, and the F66A mutant lost pore conductance
23591077 Expression of CLDN1 and CLDN10 was lower in invasive lepidic predominant adenocarcinoma than in lung adenocarcioma in situ. Overexpression of CLDN1 and CLDN10 indicates a favorable prognosis in some patients with lung adenocarcinoma.
23284715 The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein claudin 10 (CLDN10), which co-localizes with Nef mainly in the tight junction region and at the vesicular structures
22076167 Claudin 10/18 are most commonly expressed in lung adenocarcinomas. Female patients and non-smokers express these claudins more commonly suggesting that they may play a part in the carcinogenesis of tobacco unrelated carcinoma.
21647678 Claudin 10 protein is highly expressed in hepatocellular carcinoma (HCC) tissue and is closely related to angiogenesis. It could be a useful marker to predict poor prognosis of HCC patients after hepatectomy.
21370593 CLDN10 is a novel biomarker for detecting ovarian cancer in the chicken, a suitable animal model for investigating the effect and function of CLDN in human ovarian cancer.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

AA Sequence

EDFKTTNPSKQFDKNAYV                                                        211 - 228

Text Mined References (28)

PMID Year Title
26340953 2015 Claudin-3, claudin-7, and claudin-10 show different distribution patterns during decidualization and trophoblast invasion in mouse and human.
25867809 2015 High Diagnostic Accuracy Based on CLDN10, HMGA2, and LAMB3 Transcripts in Papillary Thyroid Carcinoma.
24325792 2013 The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues.
23760508 2013 Conserved aromatic residue confers cation selectivity in claudin-2 and claudin-10b.
23591077 2013 Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma.
22076167 2011 Claudins 10 and 18 are predominantly expressed in lung adenocarcinomas and in tumors of nonsmokers.
21647678 2011 Expression of claudin 10 protein in hepatocellular carcinoma: impact on survival.
21370593 2010 Claudin 10 is a glandular epithelial marker in the chicken model as human epithelial ovarian cancer.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19924644 2010 Claudins in human cancer: a review.