Property Summary

NCBI Gene PubMed Count 20
PubMed Score 2.51
PubTator Score 8.01

Knowledge Summary

Patent (1,779)

Expression

  Differential Expression (8)

Disease log2 FC p
Rheumatoid Arthritis 1.600 0.007
psoriasis 1.100 0.004
glioblastoma -1.200 0.001
medulloblastoma, large-cell -1.500 0.000
pancreatic ductal adenocarcinoma liver m... 1.002 0.019
adult high grade glioma -1.300 0.005
group 4 medulloblastoma -1.100 0.019
ovarian cancer -1.200 0.000

Synonym

Accession P78368 B5BU42 O00704 Q8WUB1 CKI-gamma 2
Symbols CK1g2

Gene

PDB

2C47  

  TechDev Info (1)

Gary Johnson Kinome profile via MIB/MS Technology

 Collection (1)

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448

Gene RIF (7)

PMID Text
19005213 These results indicate that CKIgamma2 hyperphosphorylates the serine-repeat motif of CERT, thereby inactivating CERT and down-regulating the synthesis of sphingomyelin.
18794808 Ligand-dependent ubiquitination of Smad3 is regulated by CK1g2, an inhibitor of TGF-beta signaling.
15917222 CK1epsilon and CK1gamma2 were found to bind to Per1 and to promote its degradation
15342122 Observational study of gene-disease association. (HuGE Navigator)
15300631 Data indicate that SNPs rs740423, rs2277737, rs1059684 of CSNK1G2 gene may contribute to familial febrile convulsions in children.
15300631 Observational study of gene-disease association. (HuGE Navigator)
15077195 MTA1s interacts with CKI-gamma2, which can phosphorylate MTA1s in an antiestrogen-dependent manner.Estrogen stimulates CKI-gamma2. CKI-gamma2 phosphorylates and modulates the functions of MTA1s.

AA Sequence

MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNE      1 - 70
YVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLK     71 - 140
TVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHK    141 - 210
SLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLC    211 - 280
ENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQ    281 - 350
LRDKTQPHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK         351 - 415
//

Text Mined References (26)

PMID Year Title
25500533 2014 Phosphorylation of LRRK2 by casein kinase 1? regulates trans-Golgi clustering via differential interaction with ARHGEF7.
25416956 2014 A proteome-scale map of the human interactome network.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
19946888 2010 Defining the membrane proteome of NK cells.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19369195 2009 Large-scale proteomics analysis of the human kinome.
19054851 2008 Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.
19005213 2009 Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin.
18794808 2008 Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling.
18691976 2008 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
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