Property Summary

NCBI Gene PubMed Count 35
PubMed Score 14.79
PubTator Score 15.78

Knowledge Summary

Patent (3,352)

TINX Plot

  Disease Sources (3)

Disease Target Count
Myopia 99
Schizophrenia 503
Disease Target Count P-value
ependymoma 2514 3.89595214387176E-8
acute quadriplegic myopathy 1157 1.23128271251311E-7
atypical teratoid / rhabdoid tumor 4369 7.52307619898646E-6
sonic hedgehog group medulloblastoma 1482 7.95066999192015E-6
medulloblastoma, large-cell 6234 1.52705028636375E-5
pilocytic astrocytoma 3086 1.71049834580621E-5
adult high grade glioma 2148 3.4962449193728E-5
osteosarcoma 7933 1.07660003011149E-4
ovarian cancer 8492 5.70798051251795E-4
glioblastoma 5572 9.65321151833894E-4
cystic fibrosis 1670 0.00131658310687496
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0022362621822351
Multiple myeloma 1328 0.00312011748049824
adrenocortical carcinoma 1427 0.00394940623042623
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0123245154823969
aldosterone-producing adenoma 664 0.0263102785329687
subependymal giant cell astrocytoma 2287 0.0265303616138645
Disease Target Count Z-score Confidence
Globe disease 57 0.0 2.0

Expression

Synonym

Accession P78362 A8MVX2 O75220 O75221 Q6NUL0 Q6V1X2 Q8IYQ3
Symbols SFRSK2

Gene

PDB

2X7G  

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

  TechDev Info (1)

Gary Johnson Kinome profile via MIB/MS Technology

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448

Gene RIF (11)

PMID Text
26244849 Data indicate serine/arginine-rich protein kinases SRPK1/2/SRPIN340 complexes by molecular docking and molecular dynamics.
24444330 A conserved electronegative docking groove in SRPK2 is responsible for substrate binding.
23326445 the BLRF2 RS motif is phosphorylated by SRPK2 and is important for viral replication.
20498328 Our results demonstrate that SRPK1 and SRPK2 are host factors essential for Hepatitis C virus replication.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19902070 Short-term exercise resulted in a significant increase of mRNA expression of genes encoding proteins involved in the formation of precatalytic splisosome: SRPK2.
19592491 Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.
18559500 overexpression of SRPK2 is associated with phosphorylating acinus and regulating its stimulatory effects on cyclin A1 expression, contributing to leukemia cell proliferation
18425142 SRPK2 knock down results in hypophosphorylation of the arginine-serine (RS) domain-containing human PRP28 protein (PRP28, also known as DDX23), and destabilizes PRP28 association with the tri-snRNP.
16122776 negative role of SRPK1 and SRPK2 in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein
More...

AA Sequence

MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHP      1 - 70
VKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDP     71 - 140
NKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKI    141 - 210
IHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQA    211 - 280
ELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEE    281 - 350
KEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPN    351 - 420
AESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRS    421 - 490
RTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAG    491 - 560
YSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGEL    561 - 630
RHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS                631 - 688
//

Text Mined References (48)

PMID Year Title
26244849 2015 Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340).
25416956 2014 A proteome-scale map of the human interactome network.
25056061 2014 Biological insights from 108 schizophrenia-associated genetic loci.
24444330 2014 Primary structural features of SR-like protein acinusS govern the phosphorylation mechanism by SRPK2.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23602568 2013 The protein interaction landscape of the human CMGC kinase group.
23326445 2013 An RS motif within the Epstein-Barr virus BLRF2 tegument protein is phosphorylated by SRPK2 and is important for viral replication.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23049088 2012 A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
22681889 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
More...