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Tbio
GTF2I
General transcription factor II-I

Protein Summary
Description
Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in William ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000443166
  • ENSP00000404240
  • ENSG00000263001
  • ENST00000573035
  • ENSP00000460070
  • ENST00000614986
  • ENSP00000484526
  • ENST00000620879
  • ENSP00000477837
  • ENST00000621734
  • ENSP00000482476

Symbol
  • BAP135
  • WBSCR6
  • WBS
  • DIWS
  • SPIN
  • IB291
  • BAP135
  • BTKAP1
  • TFII-I
  • WBSCR6
  • GTFII-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.99
virus perturbation
0.97
kinase
0.94
transcription factor binding site profile
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.36   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.36   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0