Tchem TUBA1B Tubulin alpha-1B chain

Protein Summary

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Uniprot Accession IDs

• P68363
• P04687
• P05209
• Q27I68
• Q8WU19

Gene Name

• TUBA1B

Ensembl ID

• ENST00000336023
• ENSP00000336799
• ENSG00000123416

Symbol

• K-ALPHA-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
molecular function	0.98
virus perturbation	0.98
protein domain	0.92

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Alpha-1b Chain

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Alpha-1b Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.13   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 575   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.13   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 575   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1