FKBP1B
Peptidyl-prolyl cis-trans isomerase FKBP1B
Protein Summary
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000380986
- ENSP00000370373
- ENSG00000119782
- ENST00000380991
- ENSP00000370379
- FKBP12.6
- FKBP1L
- FKBP9
- OTK4
- OTK4
- FKBP1L
- PKBP1L
- PPIase
- FKBP12.6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
small molecule perturbation | 0.72 | ||
kinase perturbation | 0.71 | ||
tissue sample | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.16 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 112 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.16 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 112 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 39
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3