Tclin | Troponin C, slow skeletal and cardiac muscles |
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]
Comments
Disease | Target Count |
---|---|
Congestive heart failure | 36 |
Disease | Target Count | P-value |
---|---|---|
non-small cell lung cancer | 2798 | 4.8315891390923E-43 |
lung carcinoma | 2844 | 2.80560145607095E-22 |
lung adenocarcinoma | 2714 | 8.63720895575237E-22 |
malignant mesothelioma | 3163 | 2.96482416387211E-9 |
pituitary cancer | 1972 | 4.28845033407522E-8 |
lung cancer | 4473 | 5.54734000275239E-6 |
psoriasis | 6685 | 6.7191435497327E-5 |
interstitial cystitis | 2299 | 7.1864055675848E-4 |
colon cancer | 1475 | 0.0168522635102471 |
Endometriosis | 535 | 0.0279370183875299 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Dilated cardiomyopathy | 51 | 0.0 | 5.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Cardiomyopathy | 110 | 0.0 | 4.0 |
Disease | Target Count |
---|---|
Cardiomyopathy, Dilated, 1z | 1 |
Familial isolated dilated cardiomyopathy | 41 |
hypertrophic cardiomyopathy 13 | 1 |
Disease | Target Count |
---|---|
Cardiomyopathy, dilated 1Z | 1 |
Cardiomyopathy, familial hypertrophic 13 | 1 |
Disease | log2 FC | p |
---|---|---|
malignant mesothelioma | 3.800 | 0.000 |
psoriasis | -3.000 | 0.000 |
non-small cell lung cancer | -4.464 | 0.000 |
colon cancer | 1.100 | 0.017 |
lung cancer | -2.100 | 0.000 |
interstitial cystitis | -1.100 | 0.001 |
lung adenocarcinoma | -3.200 | 0.000 |
Endometriosis | -1.358 | 0.028 |
lung carcinoma | -1.900 | 0.000 |
pituitary cancer | -2.400 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
AID | Type | Active / Inconclusive / Inactive | Description |
---|---|---|---|
493008 | screening |
801 / 0 / 334660 | Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) |
493018 | summary |
0 / 0 / 0 | Summary of the probe development efforts to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) |
493244 | screening |
390 / 0 / 335070 | Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) |
504337 | summary |
0 / 0 / 0 | Summary of the probe development efforts to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) |
504383 | screening |
1166 / 0 / 1301 | Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) |
504635 | screening |
30 / 0 / 328 | Fluorescence-based biochemical high throughput confirmation assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) |
504698 | confirmatory |
76 / 0 / 168 | Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) |
504742 | confirmatory |
14 / 0 / 18 | Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) |
602231 | other |
0 / 0 / 4 | Assay provider mechanism-of-action assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF): biochemical assay to identify activators of the Ca2+-sensitivity of cardiac muscle contraction/tension |
602232 | other |
2 / 0 / 14 | Assay provider mechanism-of-action assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF): absorbance-based biochemical assay to identify sensitizers of the Ca2+ sensitivity of cardiac myofibrillar ATPase |
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PMID | Text |
---|---|
26341255 | We used nuclear magnetic resonance and circular dichroism to solve the structure and characterize the backbone dynamics and stability of the regulatory domain of cTnC with the L29Q mutation. |
26304555 | conclusive evidence that TNNC1 is an uncommon but definitive HCM-susceptibility gene |
26232335 | Mutations in cTnC have been associated with hypertrophic or dilated cardiomyopathy.[review] |
26111167 | Troponin C (TnC) and the N-terminal helix of Troponin I (TnI N-helix), which occurs in vivo during muscle contraction. |
25996354 | Data suggest that mutation A162H in switch region of troponin I induces transitory curved conformation and promotes contraction of troponin I bound to regulatory domain of troponin C; this is countered by residue E164 to ensure proper relaxation. |
25277212 | FAK/CREB/TNNC1 has a role in mediating the effect of stromal MFAP5 on ovarian cancer metastatic potential |
25246568 | Data indicate that domain positioning impacts the effective concentration of cardiac isoform of troponin I (cTnI) presented to cardiac troponin C (cTnC). |
25101951 | The conformational dynamics of N-terminal lobe of TnC plays an important role in the regulation of cardiac muscle contraction. |
24744096 | in vitro characterisation of six cardiac Troponin C mutations causing hypertrophic and dilated cardiomyopathies (Review) |
24650606 | Central helix point mutations decreased affinity of Ca2+ saturated cardiac TNC for TnI128-180. |
More... |
PMID | Year | Title |
---|---|---|
26341255 | 2015 | The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q. |
26304555 | 2015 | In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene. |
26232335 | 2015 | Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. |
26111167 | 2015 | Coarse-Grained Modeling of Peptide Docking Associated with Large Conformation Transitions of the Binding Protein: Troponin I Fragment-Troponin C System. |
25996354 | 2015 | Structure and Dynamics of the Acidosis-Resistant A162H Mutant of the Switch Region of Troponin I Bound to the Regulatory Domain of Troponin C. |
25277212 | 2014 | Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential. |
25246568 | 2014 | The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C. |
25101951 | 2014 | Regulatory domain of troponin moves dynamically during activation of cardiac muscle. |
24744096 | 2014 | Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies. |
24650606 | 2014 | Molecular and functional consequences of mutations in the central helix of cardiac troponin C. |
More... |