| Tclin | Troponin C, slow skeletal and cardiac muscles |
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cardiomyopathy, Dilated, 1z | 1 | 0.0 | 0.0 |
| Cardiomyopathy, Familial Hypertrophic, 13 | 1 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Congestive heart failure | 113 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 4.8e-43 |
| lung carcinoma | 2843 | 2.8e-22 |
| lung adenocarcinoma | 2716 | 1.1e-16 |
| malignant mesothelioma | 3232 | 3.0e-09 |
| pituitary cancer | 1972 | 4.3e-08 |
| lung cancer | 4740 | 5.5e-06 |
| psoriasis | 6694 | 6.7e-05 |
| interstitial cystitis | 2312 | 7.2e-04 |
| colon cancer | 1478 | 1.7e-02 |
| Endometriosis | 540 | 2.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Dilated cardiomyopathy | 56 | 0.0 | 5.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cardiomyopathy | 116 | 0.0 | 4.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Otitis Media | 52 | 3.395 | 1.7 |
| Disease | Target Count |
|---|---|
| Familial isolated dilated cardiomyopathy | 41 |
| hypertrophic cardiomyopathy 13 | 1 |
| Disease | log2 FC | p |
|---|---|---|
| colon cancer | 1.100 | 1.7e-02 |
| Endometriosis | -1.358 | 2.8e-02 |
| interstitial cystitis | -1.100 | 7.2e-04 |
| lung adenocarcinoma | -1.700 | 1.1e-16 |
| lung cancer | -2.100 | 5.5e-06 |
| lung carcinoma | -1.900 | 2.8e-22 |
| malignant mesothelioma | 3.800 | 3.0e-09 |
| non-small cell lung cancer | -4.464 | 4.8e-43 |
| pituitary cancer | -2.400 | 4.3e-08 |
| psoriasis | -3.000 | 6.7e-05 |
