| Tbio | Transcription elongation factor SPT4 |
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| pituitary cancer | 1972 | 3.9e-06 |
| psoriasis | 6694 | 4.5e-05 |
| osteosarcoma | 7950 | 2.6e-04 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 6.6e-04 |
| ovarian cancer | 8520 | 1.3e-03 |
| Multiple myeloma | 1332 | 3.4e-03 |
| lung cancer | 4740 | 5.9e-03 |
| Breast cancer | 3578 | 4.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cockayne syndrome | 60 | 3.864 | 1.9 |
| Wolf-Hirschhorn syndrome | 32 | 3.425 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | 1.800 | 4.5e-02 |
| lung cancer | 1.100 | 5.9e-03 |
| Multiple myeloma | 1.097 | 3.4e-03 |
| osteosarcoma | -1.384 | 2.6e-04 |
| ovarian cancer | 1.100 | 1.3e-03 |
| pancreatic ductal adenocarcinoma liver m... | -1.313 | 6.6e-04 |
| pituitary cancer | 1.100 | 3.9e-06 |
| psoriasis | -1.600 | 4.5e-05 |
