Property Summary

NCBI Gene PubMed Count 121
Grant Count 1,218
R01 Count 84
Funding $813,339,683.61
PubMed Score 673.08
PubTator Score 172.32

Knowledge Summary

Patent

No data available

Expression

Synonym

Accession P63261 A8K7C2 P02571 P14104 P99022 Q5U032 Q96E67
Symbols ACT
ACTG
BRWS2
DFNA20
DFNA26
HEL-176

Gene

PDB

5JLH  

Gene RIF (91)

PMID Text
26832775 a novel mutation in ACTG1 was found to be co-segregated with hearing loss and the genetic cause of autosomal dominant nonsyndromic hearing impairment in a Chinese family
26188271 Three unrelated cases of rare ACTG1 variants in fetal microlissencephaly have been described.
25792668 In this study we sought to clarify the detailed mutational spectrum, clinical features, and genotype-phenotype correlations for ACTG1 gene associated autosomal dominant sensorineural hearing loss
24762104 The actin/MKL1 signalling pathway influences cell growth and gene expression through large-scale chromatin reorganization and histone post-translational modifications.
24742657 Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution
24284654 The data, for the first time, link ASAP3 with ACTG1 in the regulation of cytoskeletal maintenance and cell motility
23875777 Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution
23874603 Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution
23811015 Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution
23756437 Mutations in ACTB cause a distinctly more severe phenotype than ACTG1 mutations in Baraitser-Winter syndrome.
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AA Sequence

MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYP      1 - 70
IEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVL     71 - 140
SLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVR    141 - 210
DIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFN    211 - 280
SIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLS    281 - 350
TFQQMWISKQEYDESGPSIVHRKCF                                                 351 - 375
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Text Mined References (127)

PMID Year Title
26832775 2016 Phenotypic Heterogeneity in a DFNA20/26 family segregating a novel ACTG1 mutation.
26228148 2015 ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.
26188271 2015 Rare ACTG1 variants in fetal microlissencephaly.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25792668 2015 Mutational spectrum and clinical features of patients with ACTG1 mutations identified by massively parallel DNA sequencing.
25416956 2014 A proteome-scale map of the human interactome network.
25241761 2014 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
24762104 2014 The actin/MKL1 signalling pathway influences cell growth and gene expression through large-scale chromatin reorganization and histone post-translational modifications.
24284654 2014 Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration.
23979707 2013 SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
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