Property Summary

NCBI Gene PubMed Count 22
PubMed Score 78.20
PubTator Score 41.21

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
glioblastoma multiforme 347 1.56038128305722E-18
astrocytoma 1493 5.34418259402028E-18
oligodendroglioma 2849 1.33077163014285E-11
atypical teratoid / rhabdoid tumor 4369 5.5180675832467E-4
diabetes mellitus 1663 0.00365032556511821
group 3 medulloblastoma 2254 0.00469980933714483
medulloblastoma, large-cell 6234 0.0106633961783992
Multiple myeloma 1328 0.0145683452620813
osteosarcoma 7933 0.0380671406589684
lung cancer 4473 0.0428369533424521
Disease Target Count Z-score Confidence
Metabolic acidosis 49 3.178 1.6
Campylobacteriosis 12 3.067 1.5

Expression

  Differential Expression (10)

Disease log2 FC p
Multiple myeloma 1.431 0.015
astrocytoma 1.200 0.000
glioblastoma multiforme 1.300 0.000
oligodendroglioma 1.100 0.000
osteosarcoma -1.076 0.038
group 3 medulloblastoma 1.700 0.005
atypical teratoid / rhabdoid tumor 1.400 0.001
medulloblastoma, large-cell 1.700 0.011
lung cancer -3.100 0.043
diabetes mellitus -1.100 0.004

Synonym

Accession P63220 P35265
Symbols S21
HLDF

Gene

PDB

4UG0   4V6X   5AJ0   5A2Q   5FLX  

  Ortholog (16)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA Inparanoid
Pig OMA EggNOG
Opossum EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid
C. elegans OMA Inparanoid
Fruitfly EggNOG Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Gene RIF (1)

PMID Text
23113252 HLDF protein and anti-HLDF antibodies are involved in blood pressure regulation and can be considered as biomarkers for early diagnosis of hypertension and its cerebral complications.

AA Sequence

MQNDAGEFVDLYVPRKCSASNRIIGAKDHASIQMNVAEVDKVTGRFNGQFKTYAICGAIRRMGESDDSIL      1 - 70
RLAKADGIVSKNF                                                              71 - 83
//

Text Mined References (31)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25114211 2014 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23636399 2013 Structures of the human and Drosophila 80S ribosome.
23535732 2013 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
23113252 2012 Involvement of HLDF protein and anti-HLDF antibodies in the mechanisms of blood pressure regulation in healthy individuals and patients with stable hypertension and hypertensive crisis.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22658674 2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
22223895 2012 Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-?-acetylation features.
21269460 2011 Initial characterization of the human central proteome.
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