Tbio | Small nuclear ribonucleoprotein-associated protein N |
May be involved in tissue-specific alternative RNA processing events.
This gene is located within the Prader-Willi Syndrome critical region on chromosome 15. Transcripts produced from this gene initiate at an imprinting center and are paternally-imprinted. These transcripts may be bicistronic and also encode SNRPN (small nuclear ribonucleoprotein polypeptide N) from a downstream open reading frame. The small protein represented by this gene is encoded by an evolutionarily-conserved upstream open reading frame and is localized to the nucleus. Extensive alternative splicing and promoter usage occurs in this region and the full-length nature of some of these transcripts has not been determined. Alterations in the imprinting center are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. [provided by RefSeq, Mar 2017]
This gene is located within the Prader-Willi Syndrome critical region on chromosome 15. Transcripts produced from this gene initiate at an imprinting center and are paternally-imprinted. These transcripts may be bicistronic and also encode SNRPN (small nuclear ribonucleoprotein polypeptide N) from a downstream open reading frame. The small protein represented by this gene is encoded by an evolutionarily-conserved upstream open reading frame and is localized to the nucleus. Extensive alternative splicing and promoter usage occurs in this region and the full-length nature of some of these transcripts has not been determined. Alterations in the imprinting center are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. [provided by RefSeq, Mar 2017]
Comments
Disease | Target Count | P-value |
---|---|---|
malignant mesothelioma | 3232 | 5.7e-09 |
glioblastoma | 5792 | 8.5e-09 |
adult high grade glioma | 3801 | 4.6e-08 |
sonic hedgehog group medulloblastoma | 467 | 4.9e-08 |
medulloblastoma, large-cell | 6241 | 5.9e-06 |
atypical teratoid / rhabdoid tumor | 5112 | 1.7e-05 |
ovarian cancer | 8520 | 9.2e-05 |
lung cancer | 4740 | 1.9e-04 |
intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.2e-03 |
subependymal giant cell astrocytoma | 2287 | 5.3e-03 |
Multiple myeloma | 1332 | 8.7e-03 |
intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 9.1e-03 |
ependymoma | 4679 | 3.8e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Chronic obstructive pulmonary disease | 184 | 0.0 | 1.7 |
Type 2 diabetes mellitus | 272 | 0.0 | 1.1 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Prader-Willi syndrome | 48 | 6.365 | 3.2 |
Angelman syndrome | 34 | 5.749 | 2.9 |
Disease | log2 FC | p |
---|---|---|
adult high grade glioma | -1.400 | 4.6e-08 |
atypical teratoid / rhabdoid tumor | -1.200 | 1.7e-05 |
ependymoma | -1.400 | 3.8e-02 |
glioblastoma | -1.300 | 8.5e-09 |
intraductal papillary-mucinous carcinoma... | -1.700 | 3.2e-03 |
intraductal papillary-mucinous neoplasm ... | -2.800 | 9.1e-03 |
lung cancer | 1.200 | 1.9e-04 |
malignant mesothelioma | -6.300 | 5.7e-09 |
medulloblastoma, large-cell | -1.500 | 5.9e-06 |
Multiple myeloma | 1.153 | 8.7e-03 |
ovarian cancer | -2.100 | 9.2e-05 |
sonic hedgehog group medulloblastoma | -1.100 | 4.9e-08 |
subependymal giant cell astrocytoma | -1.581 | 5.3e-03 |
SNRPC
LSM2
LSM4
SNRPA
SNRPB2
WDR77
PDCD7
PRPF3
SART3
SF3B1
PRMT5
TOE1
PRPF6
SNRNP200
PRPF8
TFIP11
TUT1
SF3B2
HTATSF1
EFTUD2
PRPF4
SNRNP35
CRTAP
XAB2
GPATCH1
DHX35
PAXBP1
SLC4A1AP
CRNKL1
DPP8
BUD31
DDX23
PRPF31
SF3A1
GEMIN8
AQR
WDR83
SNU13
SKAP2
TGS1
FARP1
SF3B4
EPB41L3
SNRNP48
CDC40
COIL
ZRSR2
SF3A3
SNRNP70
WBP4
CWF19L2
SNRPD2
CLNS1A
CCDC12
COPRS
ESS2
ISY1
NOL7
SF3A2
RNPC3
CMTR2
LSM8
MEPCE
SNRNP27
SNRPA1
GEMIN5
RBM42
RIOK1
SYF2
TXNL4A
ZMAT5
AKAP7
EAPP
SNRPD3
PRKRIP1
CD2BP2
CSTF1
LSM6
SNUPN
GPATCH11
SNRPD1
SF3B5
TRA2A
GEMIN2
TSSC4
LSM11