| Tbio | Ubiquitin-conjugating enzyme E2 B |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ependymoma | 4679 | 1.2e-08 |
| atypical teratoid / rhabdoid tumor | 5112 | 5.9e-08 |
| ovarian cancer | 8520 | 1.4e-07 |
| lung adenocarcinoma | 2716 | 2.9e-07 |
| tuberculosis and treatment for 3 months | 179 | 2.0e-06 |
| limb girdle muscular dystrophy 2A | 213 | 5.6e-06 |
| medulloblastoma, large-cell | 6241 | 9.6e-05 |
| psoriasis | 6694 | 2.9e-04 |
| primitive neuroectodermal tumor | 3035 | 5.2e-04 |
| glioblastoma | 5792 | 6.0e-04 |
| Multiple myeloma | 1332 | 2.8e-03 |
| adult high grade glioma | 3801 | 4.5e-03 |
| lung cancer | 4740 | 6.5e-03 |
| astrocytic glioma | 2597 | 2.5e-02 |
| oligodendroglioma | 2850 | 3.3e-02 |
| spina bifida | 1074 | 4.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Male infertility | 206 | 4.234 | 2.1 |
| Aggressive systemic mastocytosis | 20 | 3.05 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.100 | 4.5e-03 |
| astrocytic glioma | -1.400 | 2.5e-02 |
| atypical teratoid / rhabdoid tumor | -1.800 | 5.9e-08 |
| ependymoma | -1.200 | 1.2e-08 |
| glioblastoma | -1.300 | 6.0e-04 |
| limb girdle muscular dystrophy 2A | -1.008 | 5.6e-06 |
| lung adenocarcinoma | -1.100 | 2.9e-07 |
| lung cancer | -1.100 | 6.5e-03 |
| medulloblastoma, large-cell | -1.500 | 9.6e-05 |
| Multiple myeloma | 1.262 | 2.8e-03 |
| oligodendroglioma | -1.400 | 3.3e-02 |
| ovarian cancer | -1.300 | 1.4e-07 |
| primitive neuroectodermal tumor | -1.100 | 5.2e-04 |
| psoriasis | 1.200 | 2.9e-04 |
| spina bifida | -1.004 | 4.6e-02 |
| tuberculosis and treatment for 3 months | -1.100 | 2.0e-06 |
