Property Summary

NCBI Gene PubMed Count 302
Grant Count 37
R01 Count 30
Funding $2,924,666.04
PubMed Score 362.28
PubTator Score 161.54

Knowledge Summary


No data available


  Differential Expression (21)

 GWAS Trait (1)

Gene RIF (126)

27401462 Results indicate that HuR induces 14-3-3zeta translation via interaction with its 3' UTR and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding.
26906158 this study suggests that the down-regulation of 14-3-3 zeta leads to the inhibition of TGFb1- induced contraction by decreasing the expression of total RhoA in TM cells.
26884855 14-3-3zeta regulates HIF-1alpha production in hepatocellular carcinoma cells by directly binding to HIF-1alpha and via PI3K/Akt/NF-small ka, CyrillicB signal transduction pathway.
26616734 CEP131 is the key regulatory target of MK2 and 14-3-3 in centriolar satellite remodeling.
26429164 loss of expression or even the down-regulation of c-abl, but not WYHAZ, is a fundamental event that leads to genesis and progression of tumors
26295714 This study provides the molecular basis for C-Raf C-terminal-derived phosphopeptide interaction with 14-3-3zeta protein and gives structural insights responsible for phosphorylation-mediated protein binding.
26205494 Activation of PCTAIRE-1 is mediated through interaction with the phosphorylated form of cyclin Y in complex with 14-3-3.
25971962 C-terminal domain of Pdc interacts with the outside surface of the 14-3-3 dimer.
25861752 14-3-3z may play an important role in signaling pathway in breast cancer. Also, a high 14-3-3z expression could positively regulate growth factor receptors and protein kinase pathways
25670079 The 14-3-3zeta-driven contextual changes of Smad partners from p53 to Gli2 may serve as biomarkers and therapeutic targets of TGF-b-mediated cancer progression.

AA Sequence

YKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN                                       211 - 245

Text Mined References (323)

PMID Year Title
27401462 2016 Posttranscriptional regulation of 14-3-3? by RNA-binding protein HuR modulating intestinal epithelial restitution after wounding.
26906158 2016 Down-regulation of 14-3-3 Zeta Inhibits TGF-?1-Induced Actomyosin Contraction in Human Trabecular Meshwork Cells Through RhoA Signaling Pathway.
26884855 2015 14-3-3? up-regulates hypoxia-inducible factor-1? in hepatocellular carcinoma via activation of PI3K/Akt/NF-?B signal transduction pathway.
26616734 2015 p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26429164 2015 c-abl and YWHAZ gene expression in gastric cancer.
26295714 2015 Biophysical Characterization of Essential Phosphorylation at the Flexible C-Terminal Region of C-Raf with 14-3-3? Protein.
26205494 2015 Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.
26047703 2015 Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.
25971962 2015 Structural Characterization of Phosducin and Its Complex with the 14-3-3 Protein.