Tbio PPP3R1 Calcineurin subunit B type 1

Protein Summary

Description

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Uniprot Accession IDs

• P63098
• B2RC10
• B5MDU4
• P06705
• P15117
• Q08044
• Q53SL0

Gene Name

• PPP3R1

Ensembl ID

• ENST00000234310
• ENSP00000234310
• ENSG00000221823

Symbol

• CNA2
• CNB
• CNB
• CNB1
• CALNB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.83
transcription factor binding site profile	0.82
disease perturbation	0.79
hub protein	0.71
small molecule perturbation	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.61   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 204   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.61   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0