Property Summary

NCBI Gene PubMed Count 61
Grant Count 65
R01 Count 10
Funding $17,000,170.85
PubMed Score 56.70
PubTator Score 28.73

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (4)

Disease log2 FC p
medulloblastoma, large-cell 1.300 0.000
lung carcinoma 1.200 0.000
acute myeloid leukemia 1.700 0.040
ulcerative colitis -1.100 0.002

Synonym

Accession P62979 P02248 P02249 P02250 P14798 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BQ77 Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7
Symbols UBC
S27A
CEP80
UBA80
HEL112
UBCEP1
UBCEP80

Gene

PDB

3I3T   4UG0   4V6X   5AJ0   5A2Q   5FLX   2KHW   3K9P   3N30   3N32   3NS8   2KTF   2L0F   3TBL   2KOX   2KWU   2KWV   2L0T   2XK5   3AXC   3NHE   3NOB   3PHD   3PHW   3VDZ   4R62  

Gene RIF (7)

PMID Text
25592822 RPS27a appears to be a novel stress sensor in the cell which amplifies p53 response to arrest cell cycle.
24833360 RPS27A expression was found to have a weak inverse correlation with overexpression of multifunctional protein YB-1 in HCC tissues.
24680683 Knockdown of RPS27a inhibits the proliferation, induces cell cycle arrest and potentiates the effect of imatinib on apoptosis of K562 cells.
22716248 Gene expression profiles showed that RPS27A was down-regulated in epidermolysis bullosa subtypes.
22174317 HIV-1 Rev interacting protein, ribosomal protein S27A (RPS27A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells
21561866 S27a plays a non-redundant role in mediating p53 activation in response to ribosomal stress via interplaying with MDM2.
15647830 ubiquitin carboxyl extension protein 1 is overexpressed in prostate cancer

AA Sequence

MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLV      1 - 70
LRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHY     71 - 140
CGKCCLTYCFNKPEDK                                                          141 - 156
//

Text Mined References (75)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25592822 2015 DNA damage stress induces the expression of ribosomal protein S27a gene in a p53-dependent manner.
25527291 2015 Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.
25416956 2014 A proteome-scale map of the human interactome network.
24833360 2014 Inverse correlation of ribosomal protein S27A and multifunctional protein YB-1 in hepatocellular carcinoma.
24784582 2014 Ubiquitin is phosphorylated by PINK1 to activate parkin.
24751536 2014 PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
24680683 2014 RPS27a promotes proliferation, regulates cell cycle progression and inhibits apoptosis of leukemia cells.
24660806 2014 Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
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