Tclin PPIA Peptidyl-prolyl cis-trans isomerase A

Protein Summary

Description

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P62937
• A8K220
• P05092
• Q3KQW3
• Q567Q0
• Q6IBU5
• Q96IX3
• Q9BRU4
• Q9BTY9
• Q9UC61
• PPIase A

Gene Name

• PPIA

Ensembl ID

• ENST00000355968
• ENSP00000430817
• ENSG00000196262
• ENST00000468812
• ENSP00000419425
• ENST00000489459
• ENSP00000427976
• ENST00000620047
• ENSP00000479961

Symbol

• CYPA
• CYPA
• CYPH
• HEL-S-69p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
kinase perturbation	1
virus perturbation	1
transcription factor binding site profile	0.97

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1047.7   (req: < 5)

Gene RIFs: 212   (req: <= 3)

Antibodies: 599   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1047.7   (req: >= 5)

Gene RIFs: 212   (req: > 3)

Antibodies: 599   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 135

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1