Property Summary

NCBI Gene PubMed Count 23
Grant Count 22
R01 Count 12
Funding $9,239,181.24
PubMed Score 236.76
PubTator Score 133.66

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (1)

Disease Z-score Confidence
lung carcinoma 2,844

Expression

  Differential Expression (1)

Disease log2 FC p
lung carcinoma -1.100 0.000

Gene RIF (7)

PMID Text
22174317 HIV-1 Rev interacting protein, Finkel-Biskis-Reilly murine sarcoma virus ubiquitously expressed (FAU), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells
21550398 In 293T/17 cells, Bcl-G knockdown also attenuates UV-induced apoptosis, so that Bcl-G may constitute a common factor in the pathways by which both FAU and UV-irradiation induce apoptosis
19830698 data support a role for FAU in the regulation of platinum-resistance in ovarian cancer
19671159 siRNA-mediated downregulation of either Fau or Bcl-G expression inhibited apoptosis, and the inhibition produced by combining the two siRNAs was consistent with control of Bcl-G by Fau.
15543234 Overexpression of fau in the sense orientation induces cell death, which is inhibited both by Bcl-2 and by inhibition of caspases, in line with its proposed role in apoptosis
12860195 The C-terminal portion of the encoded protein displays antimicrobial activity against B. megaterium.
12660817 role in transforming osteogenic sarcoma cells to anchorage-independence

AA Sequence

KVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVVPTFGKKKGPNANS                 1 - 59
//

Text Mined References (28)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
23636399 2013 Structures of the human and Drosophila 80S ribosome.
22681889 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
21550398 2011 Candidate tumour suppressor Fau regulates apoptosis in human cells: an essential role for Bcl-G.
21269460 2011 Initial characterization of the human central proteome.
19830698 2010 FAU regulates carboplatin resistance in ovarian cancer.
19671159 2009 Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
16554811 2006 Human chromosome 11 DNA sequence and analysis including novel gene identification.
15883184 2005 Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes.
More...