Tchem ESRRG Estrogen-related receptor gamma

Protein Summary

Description

Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle. This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• P62508
• A8K4I0
• A8K6I2
• B3KY84
• E9PGB7
• F8W8J3
• O75454
• O96021
• Q68DA0
• Q6P274
• Q6PK28
• Q6TS38
• Q9R1F3
• Q9UNJ4

Gene Name

• ESRRG

Ensembl ID

• ENST00000359162
• ENSP00000352077
• ENSG00000196482
• ENST00000360012
• ENSP00000353108
• ENST00000361395
• ENSP00000354584
• ENST00000361525
• ENSP00000355225
• ENST00000366937
• ENSP00000355904
• ENST00000366938
• ENSP00000355905
• ENST00000366940
• ENSP00000355907
• ENST00000391890
• ENSP00000375761
• ENST00000408911
• ENSP00000386171
• ENST00000463665
• ENSP00000418629
• ENST00000487276
• ENSP00000419155
• ENST00000493603
• ENSP00000419594
• ENST00000493748
• ENSP00000417374
• ENST00000616180
• ENSP00000481528

Symbol

• ERR3
• ERRG2
• KIAA0832
• NR3B3
• ERR3
• ERRg
• NR3B3
• ERRgamma
• ERR-gamma

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.99
molecular function	0.97
protein domain	0.97
microRNA	0.78
phenotype	0.75

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Estrogen-related Receptor Gamma

Protein / Receptor / Estrogen-related Receptor Gamma

Protein / Nucleic Acid Binding / Estrogen-related Receptor Gamma

Protein / ... / C4 Zinc Finger Nuclear Receptor / Estrogen-related Receptor Gamma

DTO Classes

Protein / Nuclear Receptor / Estrogen-related Receptors / Estrogen-related Receptor Gamma

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.39   (req: < 5)

Gene RIFs: 75   (req: <= 3)

Antibodies: 463   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.39   (req: >= 5)

Gene RIFs: 75   (req: > 3)

Antibodies: 463   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1