Property Summary

NCBI Gene PubMed Count 119
Grant Count 182
R01 Count 131
Funding $16,349,277.12
PubMed Score 398.89
PubTator Score 281.07

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (13)

Synonym

Accession P62491 B2R4B6 B4DT13 P24410 Q5TZN9 Q9JLX1 Rab-11
Symbols YL8

Gene

PDB

4UJ3   4UJ4   4UJ5   4LWZ   4LX0   1OIV   1OIW   1OIX   1YZK   2D7C   2GZD   2GZH   2HV8   4C4P   4D0L   4D0M   5C46   5C4G   5EUQ  

Gene RIF (74)

PMID Text
26879265 Substituted V20 of Rab11A was found to interfere with proper localization of the water molecule, which mediated GTP hydrolysis, resulting in GTP being locked in an active form of Rab11A S20V.
26663395 Rab11a/Rab11 family-interacting protein 2-mediated VE-cadherin recycling is required for formation of adherens junctions and restoration of vascular endothelial barrier integrity.
26637356 Data (including data from studies in knockout mice) suggest Munc13-4 binds to Rab11 and regulates trafficking of Rab11-containing vesicles; Munc13-4 appears to regulate final steps of Rab11-positive vesicle docking at plasma membrane in exocytosis.
26635365 Rab11A and Rab11B differentially regulate intracellular trafficking of PAR1 through distinct endosomal sorting mechanisms
26378159 Mumps Virus release from the apical surface of polarized epithelial cells is facilitated by a Rab11-mediated transport system.
26258637 Authors show that Rab11-GMPPNP-FIP3-Rabin8 is more stable than Rab11-GMPPNP-Rabin8, owing to direct interaction between Rabin8 and FIP3 within the dual effector-bound complex.
26041286 Vaccinia virus traffics to early endosomes, where recycling endosome markers Rab11 and Rab22 are recruited to participate in subsequent virus trafficking prior to virus core uncoating in the cytoplasm.
25673875 Rab11a-knockdown cells displayed mislocalization of STX3 and the presentation of microvilli in the basolateral compartment
25446083 Rab11-dependent EGFR recycling has a role in synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M
25299335 Additionally, Rab11 recruitment is absent and Shigella-containing vacuolar rupture is delayed in the ipgD mutant that does not dephosphorylate PI(4,5)P2 into PI(5)P.
More...

AA Sequence

MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQ      1 - 70
ERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEAR     71 - 140
AFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKV    141 - 210
QCCQNI                                                                    211 - 216
//

Text Mined References (129)

PMID Year Title
26879265 2016 Molecular mechanism of constitutively active Rab11A was revealed by crystal structure of Rab11A S20V.
26663395 2016 Rab11a Mediates Vascular Endothelial-Cadherin Recycling and Controls Endothelial Barrier Function.
26637356 2016 Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.
26635365 2016 Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins.
26506309 2015 REI-1 Is a Guanine Nucleotide Exchange Factor Regulating RAB-11 Localization and Function in C. elegans Embryos.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26378159 2015 Mumps Virus Is Released from the Apical Surface of Polarized Epithelial Cells, and the Release Is Facilitated by a Rab11-Mediated Transport System.
26258637 2015 Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11.
26041286 2015 Intracellular Transport of Vaccinia Virus in HeLa Cells Requires WASH-VPEF/FAM21-Retromer Complexes and Recycling Molecules Rab11 and Rab22.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
More...