Property Summary

NCBI Gene PubMed Count 21
Grant Count 242
R01 Count 139
Funding $27,187,146.5
PubMed Score 139.23
PubTator Score 45.47

Knowledge Summary


No data available


  Differential Expression (6)

Disease log2 FC p
ependymoma -1.200 0.000
astrocytoma -1.200 0.006
glioblastoma -1.200 0.000
lung cancer 1.400 0.000
adult high grade glioma -1.200 0.000
ovarian cancer 1.500 0.001


Accession P62380 A8K8F5 O95753 Q9BWD5 Q9Z2Z0 TBP-like protein 1
Symbols TLF


PANTHER Protein Class (1)

Gene RIF (9)

26398009 miR18a exhibits a protective role in colorectal cancer (CRC) via inhibiting proliferation, invasion and migration of CRC cells by directly targeting the TBPL1 gene.
24870791 Western blotting and immunohistochemistry both indicated a higher TBPL1 protein expression level in colorectal cancer tissue. siRNA for TBPL1 transfection obviously slowed down the cell proliferation in both SW-620 and HT-29 cells.
24594805 results suggest that activation of the p21 upstream promoter is mediated by interaction between specific regions of TLP and p53
22511763 TLP mediates p53-governed transcriptional activation of the p21 upstream promoter.
19858204 the knockdown of the endogenous TLP reduced etoposide-induced apoptosis through repression of TAp63 expression. Taken together, our present study identifies a TLP-TAp63 pathway that is further implicated in stress-induced apoptosis.
19369647 Observational study of gene-disease association. (HuGE Navigator)
15767669 TLF is a functional regulator of transcription with targets distinct from those of TBP.
15673318 Observational study of gene-disease association. (HuGE Navigator)
15269281 Data show that during interphase, endogenous or exogenously expressed TRF2 is located almost exclusively in the nucleolus

AA Sequence


Text Mined References (25)

PMID Year Title
26398009 2015 Tumor suppressor microRNA-18a regulates tumor proliferation and invasion by targeting TBPL1 in colorectal cancer cells.
25416956 2014 A proteome-scale map of the human interactome network.
24958592 2014 TRF2, but not TBP, mediates the transcription of ribosomal protein genes.
24870791 2014 MiR-133b acts as a tumor suppressor and negatively regulates TBPL1 in colorectal cancer cells.
24835508 2014 Activity of the upstream TATA-less promoter of the p21(Waf1/Cip1) gene depends on transcription factor IIA (TFIIA) in addition to TFIIA-reactive TBP-like protein.
24594805 2014 Interaction between transactivation domain of p53 and middle part of TBP-like protein (TLP) is involved in TLP-stimulated and p53-activated transcription from the p21 upstream promoter.
22511763 2012 TATA-binding protein (TBP)-like protein is required for p53-dependent transcriptional activation of upstream promoter of p21Waf1/Cip1 gene.
21269460 2011 Initial characterization of the human central proteome.
19858204 2009 TATA-binding Protein (TBP)-like Protein Is Engaged in Etoposide-induced Apoptosis through Transcriptional Activation of Human TAp63 Gene.
19369647 2009 Identification of potentially damaging amino acid substitutions leading to human male infertility.