| Tbio | Small nuclear ribonucleoprotein Sm D2 |
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.
The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| sonic hedgehog group medulloblastoma | 467 | 1.3e-06 |
| lung cancer | 4740 | 2.8e-05 |
| diabetes mellitus | 1728 | 1.2e-03 |
| ovarian cancer | 8520 | 4.1e-03 |
| Multiple myeloma | 1332 | 1.0e-02 |
| Waldenstrons macroglobulinemia | 765 | 3.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| diabetes mellitus | -1.100 | 1.2e-03 |
| lung cancer | 2.000 | 2.8e-05 |
| Multiple myeloma | 1.212 | 1.0e-02 |
| ovarian cancer | -1.100 | 4.1e-03 |
| sonic hedgehog group medulloblastoma | 1.300 | 1.3e-06 |
| Waldenstrons macroglobulinemia | 1.093 | 3.9e-02 |
