Property Summary

NCBI Gene PubMed Count 49
Grant Count 34
R01 Count 7
Funding $3,208,312.32
PubMed Score 253.46
PubTator Score 122.65

Knowledge Summary


No data available


  Differential Expression (18)

Disease log2 FC p
astrocytoma -1.800 0.000
ependymoma -2.200 0.000
oligodendroglioma -2.000 0.000
glioblastoma -2.600 0.000
osteosarcoma 1.355 0.001
medulloblastoma -2.600 0.000
non diabetic and post-ischemic heart fai... -1.100 0.036
atypical teratoid / rhabdoid tumor -3.400 0.000
medulloblastoma, large-cell -2.800 0.000
primitive neuroectodermal tumor -2.100 0.000
tuberculosis -1.200 0.000
lung cancer 1.100 0.001
adult high grade glioma -2.600 0.000
pilocytic astrocytoma -2.900 0.000
lung adenocarcinoma 1.500 0.000
inflammatory breast cancer 1.100 0.037
Pick disease 1.200 0.001
ovarian cancer 1.200 0.000

Gene RIF (24)

27033453 Lithium normalizes gamma band oscillations mediated by P/Q-type calcium channels modulated by NCS-1.
26153708 Study determined the salient features of the folding free-energy landscapes of the Mg2+-bound and apo states of NCS-1
25565019 A strong liason was characterized between myristoylation and cryptic EF-1 in NCS-1.
25343687 results reveal the important role of salt bridges on the structural properties of NCS-1 protein and that R102Q mutation disables the dynamic relocation of C-terminus, which may block the binding of NCS-1 protein to its receptors
25157171 single-molecule optical tweezers were used to monitor misfolding reactions of the human neuronal calcium sensor-1.
24934288 The functional link in substantia nigra dopamine neurons between Cav1.3- L-type-Ca2+ channels and D2-autoreceptor activity is an adaptive signalling network controlled by NCS-1.
24012477 NCS1 has evolved a remarkable complex interdomain cooperativity and a fundamentally different folding mechanism compared to structurally related proteins.
22999924 data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of Cocaine Abuse in individuals of African descent.
22227393 the C-terminal tail is important for regulating the conformational stability of NCS1 in Ca(2+)-activated state
21875085 analysis of the interaction between the D2 dopamine receptor and neuronal calcium sensor-1

AA Sequence


Text Mined References (52)

PMID Year Title
27033453 2016 Lithium decreases the effects of neuronal calcium sensor protein 1 in pedunculopontine neurons.
26705828 2016 Membrane binding of Neuronal Calcium Sensor-1 (NCS1).
26153708 2015 Single-molecule folding mechanisms of the apo- and Mg(2+)-bound states of human neuronal calcium sensor-1.
25565019 2015 Liaison between myristoylation and cryptic EF-hand motif confers Ca(2+) sensitivity to neuronal calcium sensor-1.
25416956 2014 A proteome-scale map of the human interactome network.
25343687 2014 R102Q mutation shifts the salt-bridge network and reduces the structural flexibility of human neuronal calcium sensor-1 protein.
25255805 2014 Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
25157171 2014 Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1.
24934288 2014 Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.
24012477 2013 Single-molecule folding mechanism of an EF-hand neuronal calcium sensor.