Property Summary

NCBI Gene PubMed Count 49
PubMed Score 253.46
PubTator Score 122.65

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Alzheimer's disease 644
Disease Target Count P-value
astrocytoma 1493 2.63136124015997E-26
oligodendroglioma 2849 9.04480145840807E-23
ependymoma 2514 3.09091938207545E-14
atypical teratoid / rhabdoid tumor 4369 8.38534050249787E-11
pilocytic astrocytoma 3086 1.45336579110015E-10
ovarian cancer 8492 1.52881733055832E-10
medulloblastoma 1524 5.44213880428832E-9
glioblastoma 5572 4.85802267353878E-8
adult high grade glioma 2148 3.69901372044004E-6
medulloblastoma, large-cell 6234 3.69916597756373E-6
lung adenocarcinoma 2714 3.77505099882893E-6
tuberculosis 1563 7.81642979757739E-6
primitive neuroectodermal tumor 3031 2.02571632558518E-5
osteosarcoma 7933 6.96008009921036E-4
Pick disease 1893 0.00102714266059438
lung cancer 4473 0.00106095374141341
non diabetic and post-ischemic heart failure 200 0.0355112495340954
inflammatory breast cancer 404 0.0369915582845548


  Differential Expression (18)

Disease log2 FC p
astrocytoma -1.800 0.000
ependymoma -2.200 0.000
oligodendroglioma -2.000 0.000
glioblastoma -2.600 0.000
osteosarcoma 1.355 0.001
medulloblastoma -2.600 0.000
non diabetic and post-ischemic heart fai... -1.100 0.036
atypical teratoid / rhabdoid tumor -3.400 0.000
medulloblastoma, large-cell -2.800 0.000
primitive neuroectodermal tumor -2.100 0.000
tuberculosis -1.200 0.000
lung cancer 1.100 0.001
adult high grade glioma -2.600 0.000
pilocytic astrocytoma -2.900 0.000
lung adenocarcinoma 1.500 0.000
inflammatory breast cancer 1.100 0.037
Pick disease 1.200 0.001
ovarian cancer 1.200 0.000


Accession P62166 E9PAY3 P36610 Q9UK26 NCS-1
Symbols FLUP



1G8I   2LCP   4GUK  

  Ortholog (12)

 MGI Term (1)

Pathway (1)

Gene RIF (24)

27033453 Lithium normalizes gamma band oscillations mediated by P/Q-type calcium channels modulated by NCS-1.
26153708 Study determined the salient features of the folding free-energy landscapes of the Mg2+-bound and apo states of NCS-1
25565019 A strong liason was characterized between myristoylation and cryptic EF-1 in NCS-1.
25343687 results reveal the important role of salt bridges on the structural properties of NCS-1 protein and that R102Q mutation disables the dynamic relocation of C-terminus, which may block the binding of NCS-1 protein to its receptors
25157171 single-molecule optical tweezers were used to monitor misfolding reactions of the human neuronal calcium sensor-1.
24934288 The functional link in substantia nigra dopamine neurons between Cav1.3- L-type-Ca2+ channels and D2-autoreceptor activity is an adaptive signalling network controlled by NCS-1.
24012477 NCS1 has evolved a remarkable complex interdomain cooperativity and a fundamentally different folding mechanism compared to structurally related proteins.
22999924 data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of Cocaine Abuse in individuals of African descent.
22227393 the C-terminal tail is important for regulating the conformational stability of NCS1 in Ca(2+)-activated state
21875085 analysis of the interaction between the D2 dopamine receptor and neuronal calcium sensor-1

AA Sequence


Text Mined References (52)

PMID Year Title
27033453 2016 Lithium decreases the effects of neuronal calcium sensor protein 1 in pedunculopontine neurons.
26705828 2016 Membrane binding of Neuronal Calcium Sensor-1 (NCS1).
26153708 2015 Single-molecule folding mechanisms of the apo- and Mg(2+)-bound states of human neuronal calcium sensor-1.
25565019 2015 Liaison between myristoylation and cryptic EF-hand motif confers Ca(2+) sensitivity to neuronal calcium sensor-1.
25416956 2014 A proteome-scale map of the human interactome network.
25343687 2014 R102Q mutation shifts the salt-bridge network and reduces the structural flexibility of human neuronal calcium sensor-1 protein.
25255805 2014 Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
25157171 2014 Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1.
24934288 2014 Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.
24012477 2013 Single-molecule folding mechanism of an EF-hand neuronal calcium sensor.