Property Summary

NCBI Gene PubMed Count 38
PubMed Score 13.35
PubTator Score 49.92

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
atypical teratoid / rhabdoid tumor 4369 6.06068826022083E-7
ovarian cancer 8492 4.93113424943392E-6
medulloblastoma, large-cell 6234 1.19502925610113E-5
cystic fibrosis 1670 1.28638743599662E-5
lung cancer 4473 1.49900181863559E-5
Amyotrophic Lateral Sclerosis 432 1.80087838347832E-5
osteosarcoma 7933 1.50373041962634E-4
group 4 medulloblastoma 1875 3.56636887970856E-4
glioblastoma 5572 3.75181696421431E-4
pituitary cancer 1972 4.17666421905864E-4
adult high grade glioma 2148 6.48486357763133E-4
Breast cancer 3099 6.61765858522334E-4
head and neck cancer 270 8.65263859465496E-4
ependymoma 2514 0.00108443009039184
astrocytic glioma 2241 0.0012463865601126
primary pancreatic ductal adenocarcinoma 1271 0.0041621721836493
pancreatic cancer 2300 0.00427183081971447
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00482840233416582
oligodendroglioma 2849 0.00623772416035101
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00674014814823564
progressive supranuclear palsy 674 0.00724630979418974
Pick disease 1893 0.00811160047831556
active Crohn's disease 918 0.00991883612956729
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0114133564669553
active ulcerative colitis 477 0.0132038062537914
X-linked cerebral adrenoleukodystrophy 115 0.0268004424257739


Gene RIF (26)

26048572 Lmo4 participates in the regulation of lung epithelial cell proliferation but is not essential for tumor progression.
25310299 LMO4 appears to form a hub in protein-protein interaction networks, linking numerous pathways within cells.
25079073 Clim2, in a complex with LMO4, supports mammary stem cells by directly targeting the Fgfr2 promoter in basal cells to increase its expression
25057208 Existence of a region in the lateral portion of the mammalian cochlea that is competent to make an organ of Corti is demonstrated in the absence of LMO4 function.
23407937 the association of high levels of LMO4 with aggressive neuroblastomas is dependent on LMO4 regulation of cadherin expression and hence, tumor invasiveness
23407556 Low LMO4 mRNA levels were associated with response to erlotinib in non-small-cell lung cancer.
23353824 Data suggest that overexpression of LMO4 may disrupt some of the normal tumour suppressor activities of CtIP, thereby contributing to breast cancer progression.
23291272 oncoprotein HBXIP is able to activate the transcriptional coregulatory protein LMO4 through transcription factor Sp1 in promotion of proliferation of breast cancer cells.
22906635 LMO4 is a direct target of p53 and inhibits p53-mediated proliferative inhibition of breast cancer cells through interacting p53
21362019 LMO4 expression in squamous cell carcinoma of the anterior tongue

AA Sequence

RPTALINGHLNSLQSNPLLPDQKVC                                                 141 - 165

Text Mined References (38)

PMID Year Title
26048572 2015 The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression.
25416956 2014 A proteome-scale map of the human interactome network.
25310299 2014 The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.
25079073 2014 The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis.
25057208 2014 LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea.
24379077 2014 LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins.
23407937 2013 LMO4 is an essential cofactor in the Snail2-mediated epithelial-to-mesenchymal transition of neuroblastoma and neural crest cells.
23407556 2013 BRCA1, LMO4, and CtIP mRNA expression in erlotinib-treated non-small-cell lung cancer patients with EGFR mutations.
23353824 2013 Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8.
23291272 2013 The oncoprotein HBXIP activates transcriptional coregulatory protein LMO4 via Sp1 to promote proliferation of breast cancer cells.