| Tbio | Protein transport protein Sec61 subunit alpha isoform 1 |
Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins. Plays a role in pronephric kidney tubule development (By similarity).
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Craniofacial Abnormalities | 151 | 0.0 | 0.0 |
| HYPERURICEMIC NEPHROPATHY, FAMILIAL JUVENILE, 4 | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 3.4e-15 |
| glioblastoma | 5792 | 1.6e-11 |
| Astrocytoma, Pilocytic | 3081 | 2.3e-07 |
| medulloblastoma, large-cell | 6241 | 4.0e-07 |
| tuberculosis and treatment for 3 months | 179 | 7.5e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 9.6e-07 |
| ovarian cancer | 8520 | 2.1e-06 |
| adult high grade glioma | 3801 | 3.2e-05 |
| psoriasis | 6694 | 7.2e-05 |
| osteosarcoma | 7950 | 2.1e-04 |
| group 4 medulloblastoma | 1855 | 2.5e-04 |
| primitive neuroectodermal tumor | 3035 | 7.8e-04 |
| oligodendroglioma | 2850 | 1.3e-03 |
| ependymoma | 4679 | 1.6e-03 |
| astrocytic glioma | 2597 | 1.6e-03 |
| Multiple myeloma | 1332 | 2.1e-03 |
| subependymal giant cell astrocytoma | 2287 | 5.6e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 6.1e-03 |
| invasive ductal carcinoma | 2951 | 8.2e-03 |
| Polycystic ovary syndrome | 360 | 1.1e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.1e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 3.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Polycystic liver disease | 16 | 4.224 | 2.1 |
| Cataract 8 multiple types | 33 | 3.16 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.100 | 3.2e-05 |
| astrocytic glioma | 1.100 | 1.6e-03 |
| Astrocytoma, Pilocytic | 1.100 | 2.3e-07 |
| atypical teratoid / rhabdoid tumor | 1.100 | 9.6e-07 |
| ependymoma | 1.300 | 1.6e-03 |
| glioblastoma | 1.300 | 1.6e-11 |
| group 4 medulloblastoma | 2.400 | 2.5e-04 |
| intraductal papillary-mucinous adenoma (... | -1.100 | 6.1e-03 |
| intraductal papillary-mucinous carcinoma... | -1.100 | 1.1e-02 |
| invasive ductal carcinoma | 1.200 | 8.2e-03 |
| medulloblastoma, large-cell | 3.000 | 4.0e-07 |
| Multiple myeloma | 1.113 | 2.1e-03 |
| non-small cell lung cancer | 1.600 | 3.4e-15 |
| oligodendroglioma | 1.300 | 1.3e-03 |
| osteosarcoma | 1.838 | 2.1e-04 |
| ovarian cancer | 2.200 | 2.1e-06 |
| pancreatic ductal adenocarcinoma liver m... | -1.720 | 3.2e-02 |
| Polycystic ovary syndrome | -1.599 | 1.1e-02 |
| primitive neuroectodermal tumor | 1.200 | 7.8e-04 |
| psoriasis | 1.100 | 7.2e-05 |
| subependymal giant cell astrocytoma | 1.474 | 5.6e-03 |
| tuberculosis and treatment for 3 months | -1.100 | 7.5e-07 |
MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILA 1 - 70 SNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDP 71 - 140 SEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFE 141 - 210 GAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYP 211 - 280 IKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPES 281 - 350 FGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTA 351 - 420 AAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF 421 - 476 //
