Tbio NCALD Neurocalcin-delta

Protein Summary

Description

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions. This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P61601
• P29554
• Q8IYC3
• Q9H0W2

Gene Name

• NCALD

Ensembl ID

• ENST00000220931
• ENSP00000220931
• ENSG00000104490
• ENST00000311028
• ENSP00000310587
• ENST00000395923
• ENSP00000379256
• ENST00000519508
• ENSP00000430476
• ENST00000521599
• ENSP00000428105

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
disease perturbation	0.74
transcription factor	0.71
small molecule perturbation	0.7
disease	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.2   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.2   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0