Property Summary

NCBI Gene PubMed Count 710
PubMed Score 3096.48
PubTator Score 1649.09

Knowledge Summary


No data available


  Disease Sources (5)



Accession P61586 P06749 Q53HM4 Q5U024 Q9UDJ0 Q9UEJ4
Symbols ARHA



2RGN   5JCP   5HPY   1S1C   4D0N   1X86   1CC0   1XCG   3KZ1   3T06   1A2B   1CXZ   1DPF   1FTN   1KMQ   1LB1   1OW3   1TX4   3LW8   3LWN   3LXR   3MSX   4XH9   4XOI   4XSG   4XSH   5A0F   5BWM   5C2K   5C4M   5FR1   5FR2   5IRC  

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Mouse OMA Inparanoid
Rat OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (583)

27126939 Listeria monocytogenes infection could promote host cell apoptosis and down-regulate RhoA expression.
27097314 FGF-2, VEGF-A, and HIV-Tat, may affect the glomerular filtration barrier in HIV+ children through the induction of synergistic changes in Rho-A and Src activity
26976596 RhoA-ROCK-Rnd3 feedback loop determined the local reassembly sites of the actin cortex during membrane blebbing.
26928204 Uniaxial stretch activates JNK1 via RhoA and ROCK pathways in human bladder smooth muscle cells.
26900962 knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4), ITGA5, and integrin beta 1 (ITGB1); otherwise, RhoA expression was significantly decreased
26852662 Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/beta-arrestin 2/Rho A signaling pathway.
26830684 CD24 regulates EGFR signaling by inhibiting EGFR internalization and degradation in a RhoA-dependent manner in gastric cancer cells.
26752649 These findings uncover deficient prenylation of Rho-A as a key player in the pathogenesis of IBDs.
26751560 As a p53 target, GLS2 mediates p53's function in metastasis suppression through inhibiting Rac1.
26741994 The knockdown of RhoA protein in the HCMV infected cell lines restored their proliferation rate.

AA Sequence


Text Mined References (725)

PMID Year Title
27126939 2016 [Increased apoptosis and down-regulation of RhoA in HepG2 cells infected by Listeria monocytogenes].
27097314 2016 Circulating Fibroblast Growth Factor-2, HIV-Tat, and Vascular Endothelial Cell Growth Factor-A in HIV-Infected Children with Renal Disease Activate Rho-A and Src in Cultured Renal Endothelial Cells.
26976596 2016 A RhoA and Rnd3 cycle regulates actin reassembly during membrane blebbing.
26928204 2016 Uni-axial stretch induces actin stress fiber reorganization and activates c-Jun NH2 terminal kinase via RhoA and Rho kinase in human bladder smooth muscle cells.
26900962 2016 Alteration of Pituitary Tumor Transforming Gene-1 Regulates Trophoblast Invasion via the Integrin/Rho-Family Signaling Pathway.
26852662 2016 Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/?-arrestin 2/Rho A signaling pathway.
26830684 2016 CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric cancer cells.
26752649 2016 Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation.
26751560 2016 Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.
26741994 2016 The Role of RhoA, RhoB and RhoC GTPases in Cell Morphology, Proliferation and Migration in Human Cytomegalovirus (HCMV) Infected Glioblastoma Cells.