Tbio OSTN Osteocrin

Protein Summary

Description

Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782). Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).

Uniprot Accession IDs

• P61366
• A1A4U3

Gene Name

• OSTN

Ensembl ID

• ENST00000339051
• ENSP00000342356
• ENSG00000188729

Symbol

• MUSCLIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.58
tissue	0.58
cell line	0.49
disease	0.37
biological term	0.36

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.58   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.58   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0