Property Summary

NCBI Gene PubMed Count 33
PubMed Score 178.59
PubTator Score 25.68

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 7.21487272108913E-26
juvenile dermatomyositis 1189 8.11754754915526E-9
Duchenne muscular dystrophy 602 2.35089144634089E-8
glioblastoma 5572 3.38989817485474E-4
ovarian cancer 8492 0.00164504007973881
subependymal giant cell astrocytoma 2287 0.00434341266704779
osteosarcoma 7933 0.00687905938595162
pancreatic cancer 2300 0.0113175464052739
primary pancreatic ductal adenocarcinoma 1271 0.0140647950629297
medulloblastoma, large-cell 6234 0.0202113102605869
oligodendroglioma 2849 0.0208252407897333
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0217300868940429
dermatomyositis 967 0.0246843642163097
Breast cancer 3099 0.0259889637897627
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0344803569411372
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0393229947592628
astrocytic glioma 2241 0.0412435583162826
cutaneous lupus erythematosus 1056 0.0417281676982602



Accession P61225 P17964 Q96EG5 Q9CXG0



1N4P   1N4Q   1N4R  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid

 GO Function (2)

Gene RIF (14)

26308105 Expression and DNA methylation status of the Rap2B gene in human bronchial epithelial cells treated by cigarette smoke condensate
25762091 Rap2B itself is not necessary for p53-dependent cell cycle arrest.
25663460 Our collective findings provide preliminary evidence that miR-342-3p acts as a tumor suppressor in small cell lung cancer through repression of RAP2B.
24951956 Data indicate that rap GTP-binding protein Rap2B expression is significantly increased in suprarenal epithelioma and Rap2B can promote the cell migration and invasion abilities, suggesting a target for the treatment of suprarenal epithelioma.
24586238 Prostaglandin E2-mediated HIV-1 inhibition requires the EPAC/RAP/RhoA signaling pathway by downregulation of HIV-1 CA production
23535297 Rap2b is a conserved p53-activated gene that counters p53-mediated apoptosis after DNA damage.
23535297 Rap2b mediates the pro-survival function of p53 upon DNA damage.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20471030 This protein has been found differentially expressed in thalami from patients with schizophrenia.
19913121 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence


Text Mined References (37)

PMID Year Title
26308105 2015 Expression and DNA methylation status of the Rap2B gene in human bronchial epithelial cells treated by cigarette smoke condensate.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25762091 2015 p53 target gene Rap2B regulates the cytoskeleton and inhibits cell spreading.
25663460 2015 miR-342-3p targets RAP2B to suppress proliferation and invasion of non-small cell lung cancer cells.
25416956 2014 A proteome-scale map of the human interactome network.
24951956 2014 Rap2B promotes migration and invasion of human suprarenal epithelioma.
23885123 2013 JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
23535297 2013 Rap2b, a novel p53 target, regulates p53-mediated pro-survival function.
22797597 2012 Rap2A links intestinal cell polarity to brush border formation.
21269460 2011 Initial characterization of the human central proteome.