Property Summary

NCBI Gene PubMed Count 74
PubMed Score 72.53
PubTator Score 154.48

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
IGA Glomerulonephritis 454
Disease Target Count P-value
ovarian cancer 8492 3.50279824268271E-7
juvenile dermatomyositis 1189 4.23937744721233E-6
lung adenocarcinoma 2714 7.65820236768046E-6
Pick disease 1893 2.55510455746074E-5
primary Sjogren syndrome 789 5.70319924218488E-5
osteosarcoma 7933 7.00040169030686E-5
psoriasis 6685 7.46748494073069E-4
oligodendroglioma 2849 0.00128895575211037
dermatomyositis 967 0.00297989889676929
pancreatic cancer 2300 0.00384509348473672
ependymoma 2514 0.0052145199502725
acute quadriplegic myopathy 1157 0.00551747234802687
progressive supranuclear palsy 674 0.00556017100723865
breast carcinoma 1614 0.00615753433403714
ductal carcinoma in situ 1745 0.00672865933655376
primary pancreatic ductal adenocarcinoma 1271 0.0077501936725345
Waldenstrons macroglobulinemia 765 0.0105378419664392
hereditary spastic paraplegia 313 0.0114471795696902
group 4 medulloblastoma 1875 0.0116065829573018
pancreatic carcinoma 567 0.0131047951308072
Parkinson's disease 364 0.0172814559154072
astrocytic glioma 2241 0.0186869637926785
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0196969087292616
Breast cancer 3099 0.0215510499526643
Alzheimer's disease 644 0.0303469390174222
axial spondyloarthropathy 28 0.046126830192839
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0482336089053804
Disease Target Count Z-score Confidence
Wiskott-Aldrich syndrome 27 4.063 2.0



Accession P61160 B2RCP5 D6W5F4 E9PF41 O15142 Q96C82
Symbols ARP2


  Ortholog (18)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG
Zebrafish OMA Inparanoid
C. elegans OMA Inparanoid
Fruitfly OMA EggNOG Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Gene RIF (37)

26997484 Kv3.3 regulates Arp2/3-dependent cortical actin nucleation mediated by Hax-1; resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia type 13.
26655834 demonstrate that the Arp2/3 complex in higher eukaryotes is actually a family of complexes with different properties
26370503 Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo.
26028144 Platelet actin nodule formation is dependent on WASp and the ARP2/3 complex.
25264243 The loss of the Arp2/3 complex acts as a stress that initiates cell cycle arrest by triggering p16INK4a/p14Arf transcription.
24918434 Coronin3 can regulate gastric cancer (GC) invasion and metastasis through Arp2, and the combination of Coronin3 and Arp2 provides a potential marker for predicting GC prognosis.
24872192 study unveils an ARP2/3:VCA-independent function of nuclear-WASp in TH1 gene activation that is uncoupled from its cytoplasmic role in actin polymerization.
24469447 Cortactin has a role as a scaffold for Arp2/3 and WAVE2 at the epithelial zonula adherens
24344184 The Arp2/Arp3 complex has a role in osmotic signaling.
23212915 Neural Wiskott-Aldrich syndrome protein (N-WASP)-mediated p120-catenin interaction with Arp2-Actin complex stabilizes endothelial adherens junctions.

AA Sequence


Text Mined References (81)

PMID Year Title
26997484 2016 Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.
26655834 2016 Isoform diversity in the Arp2/3 complex determines actin filament dynamics.
26370503 2015 ?5?1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3.
26028144 2015 Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25264243 2014 Divide and conquer: the surprising link between motility and the cell cycle (retrospective on DOI 10.1002/bies.201200119).
24918434 2014 Coronin3 regulates gastric cancer invasion and metastasis by interacting with Arp2.
24872192 2014 Nuclear role of WASp in gene transcription is uncoupled from its ARP2/3-dependent cytoplasmic role in actin polymerization.
24469447 2014 Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens.
24344184 2013 Loss of Arp2/3 induces an NF-?B-dependent, nonautonomous effect on chemotactic signaling.