Property Summary

NCBI Gene PubMed Count 75
PubMed Score 16.84
PubTator Score 42.85

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
Breast cancer 3099 1.53832693584244E-32
non-small cell lung cancer 2798 6.9143662194343E-16
juvenile dermatomyositis 1189 1.24754463328804E-13
posterior fossa group A ependymoma 1511 1.76953383364887E-7
Duchenne muscular dystrophy 602 1.1847921930828E-6
acute quadriplegic myopathy 1157 4.32266597827923E-6
tuberculosis and treatment for 6 months 686 1.24672063586262E-5
ovarian cancer 8492 2.52154287148264E-5
Amyotrophic Lateral Sclerosis 432 4.92304883543889E-5
psoriasis 6685 4.63377058171847E-4
invasive ductal carcinoma 2950 7.48000381979859E-4
medulloblastoma, large-cell 6234 0.00139538058671904
Waldenstrons macroglobulinemia 765 0.0015678761074071
pancreatic cancer 2300 0.00174400961068829
glioblastoma 5572 0.00272594659983336
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00386226677111742
primary pancreatic ductal adenocarcinoma 1271 0.00457995041122856
lung cancer 4473 0.00614322743681687
dermatomyositis 967 0.00669391963760779
Multiple myeloma 1328 0.0102990504329377
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0117903842765135
hereditary spastic paraplegia 313 0.0144067315912477
aldosterone-producing adenoma 664 0.029336662940455
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0333200551425556
primary Sjogren syndrome 789 0.044776237436681
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0497756034622738
Disease Target Count Z-score Confidence
Opisthorchiasis 14 3.66 1.8
Melioidosis 11 3.124 1.6

Expression

Synonym

Accession P61158 P32391 Q53QM2
Symbols ARP3

Gene

  Ortholog (14)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog EggNOG Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG
C. elegans OMA EggNOG
S.cerevisiae OMA EggNOG

Gene RIF (41)

PMID Text
26997484 Kv3.3 regulates Arp2/3-dependent cortical actin nucleation mediated by Hax-1; resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia type 13.
26655834 demonstrate that the Arp2/3 complex in higher eukaryotes is actually a family of complexes with different properties
26370503 Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo.
26028144 Platelet actin nodule formation is dependent on WASp and the ARP2/3 complex.
26018170 HIV-1 Gag is required by RAC1-WASF2-BAIAP2-ARP3 pathway for HIV VLP production/release from Jurkat T lymphocytes
26018170 HIV-1 VLP production/release from Jurkat T lymphocytes requires an intact RAC1-WASF2-BAIAP2-ARP3 pathway as demonstrated by siRNA knockdown experiments
25264243 The loss of the Arp2/3 complex acts as a stress that initiates cell cycle arrest by triggering p16INK4a/p14Arf transcription.
24872192 study unveils an ARP2/3:VCA-independent function of nuclear-WASp in TH1 gene activation that is uncoupled from its cytoplasmic role in actin polymerization.
24469447 Cortactin has a role as a scaffold for Arp2/3 and WAVE2 at the epithelial zonula adherens
24415754 HIV-1 VLP production/release from Jurkat T lymphocytes requires an intact RAC1-WASF2-BAIAP2-ARP3 pathway as demonstrated by siRNA knockdown experiments
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AA Sequence

MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGDEAIEKP      1 - 70
TYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLY     71 - 140
IAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRD    141 - 210
REVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPE    211 - 280
IFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLS    281 - 350
EELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS      351 - 418
//

Text Mined References (84)

PMID Year Title
26997484 2016 Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.
26655834 2016 Isoform diversity in the Arp2/3 complex determines actin filament dynamics.
26370503 2015 ?5?1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3.
26028144 2015 Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25264243 2014 Divide and conquer: the surprising link between motility and the cell cycle (retrospective on DOI 10.1002/bies.201200119).
24872192 2014 Nuclear role of WASp in gene transcription is uncoupled from its ARP2/3-dependent cytoplasmic role in actin polymerization.
24469447 2014 Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens.
24344184 2013 Loss of Arp2/3 induces an NF-?B-dependent, nonautonomous effect on chemotactic signaling.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
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