You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CXCR4
C-X-C chemokine receptor type 4

Protein Summary
Description
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241393
  • ENSP00000241393
  • ENSG00000121966
  • ENST00000409817
  • ENSP00000386884

Symbol
  • FB22
  • HM89
  • LAP3
  • LCR1
  • NPYR
  • WHIM
  • CD184
  • LAP-3
  • LESTR
  • NPY3R
  • NPYRL
  • WHIMS
  • HSY3RR
  • NPYY3R
  • D2S201E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
PubMedID
0.99
transcription factor perturbation
0.99
gene perturbation
0.98
virus perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4274.44   (req: < 5)
Gene RIFs: 1597   (req: <= 3)
Antibodies: 1625   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4274.44   (req: >= 5)
Gene RIFs: 1597   (req: > 3)
Antibodies: 1625   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 386
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1